The global
hairy cell leukemia therapeutics market has been witnessing some advances in research since the beginning of the 21st century, which have led to the launch of a few novel therapies for the treatment of
hairy cell leukemia and other hematologic malignancies.
While 2.3% TUNEL-positive inner and outer
hairy cells in cochlea cross-sections were observed in the control group, it was 2.6% and 2.5% in the G.
The etiology of HCL is unknown, although a French study that evaluated occupational exposure to pesticides and development of lymphoid neoplasms among men appears to support the hypothesis that occupational pesticide exposures may correlate with development of a number of lymphoid malignancies including
hairy cell leukemia, Hodgkin lymphoma, multiple myeloma, and non-Hodgkin lymphoma [12].
* The report provides a snapshot of the global therapeutic landscape of
Hairy Cell Leukemia
This was an individual, who, 10 months following treatment with cladribine for
hairy cell leukaemia, ended her self-administration of oral contraceptives.
The neoplastic cells stained positive for CD45, CD19, CD20, CD11c, CD22, CD25, and CD103, consistent with
hairy cell leukemia.
A blood smear showed 10%
hairy cells, and a bone marrow biopsy confirmed a diagnosis of
hairy cell leukemia and interstitial infiltration of CD20-positive, monoclonal antibody DBA.44-positive, and tartrate-resistant acid phosphatase-positive cells.
Claire, of Gosforth, Newcastle, said: "It came as quite a shock to be told that I had
hairy cell leukaemia as I'd never heard of the condition before.
Although the etiology of paraneoplastic vasculitis is not yet clearly known, suggested mechanisms are: (i) vascular damage caused by cross-reactions between antibodies against tumor cells and the vascular endothelium (ii) vascular inflammation caused by immune complexes involving tumor antigens (iii) direct vascular damage caused by the
hairy cells in
hairy cell leukemia.
* Symptoms of
hairy cell leukemia include fatigue, weakness, and weight loss.
However, the gene expression profile of the icukemic cells is not the same as that of the normal counterpart and displays many similarities and differences (7), (24-27) Gene expression profile of the leukemic B cells in fbllicular lymphorna,
hairy cell leukemia and CLL has been shown to resemble the germinal center or the memory stage of differentiati on (7), (24), (28), (29).
