hairy cell


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hairy cell

(hâr′ē)
n.
A white blood cell having multiple surface projections and characteristically present in hairy cell leukemia.
Haematology A round or ovoid, 12–20-µm peripheral blood cell characterised by filamentous projections that are fine/hairy by phase contrast and electron microscopy, but thick or smudged and irregular by light microscopy; hairy cells are monotonously uniform in appearance; the nucleus is ovoid and may be indented, and usually central, but may be eccentric with 1+ nucleoli; the chromatin is fine or slightly coarse; the moderate amount of cytoplasm stains pale blue; N:C ratio is 4:1 to 2:1

hair·y cell

(hār'ē sel)
Medium-sized leukocytes that have features of reticuloendothelial cells and multiple cytoplasmic projections (hairs) on the cell surface, but may be a variety of B lymphocyte; found in hairy cell leukemia.
References in periodicals archive ?
Pyrosequencing of BRAF V600E in routine samples of hairy cell leukaemia identifies CD5+ variant hairy cell leukaemia that lacks V600E.
of Cases (%) Cryptosporidial diarrhea(C parvum) 4(4) Cryptococcal meningitis 15(14) Tuberculosis: (i) Extrapulmonary 16(15) (ii) Pulmonary 24(23) Pneumocystis carinii pneumonia(PCP) 3(3) Cerebral toxoplasmosis 5(5) Penicillium marneffei 5(5) Herpes zoster 14(14) Viral meningitis 2(2) Oral candidiasis 22(21) Hepatitis B virus 11(11) Hepatitis C virus 24(23) Cytomegalovirus infection (CMV) 2(2) Kaposis's sarcoma 1(1) Hairy cell leukoplakia 1(1) Table 5: Distribution of HIV seropositive cases with respect to associated diseases Associated Diseases No.
Hairy cell leukemia expresses bright pan-B-cell antigens and, uniquely among B-cell neoplasms, strongly expresses CD11c, CD25, CD103, CD123, and annexin A1 typical ly.
One of 4 LPL/WM cases (25%) and 1 of 3 hairy cell leukemia cases (33%) showed a heterogeneous positive pattern, whereas the remaining cases showed a homogeneous negative pattern (Table 1).
Topics that will be discussed include B-cell small lymphocytic lymphoma/leukemia, lymphoplasmacytic lymphoma, extranodal marginal zone (MALT) lymphoma, follicular lymphoma, mantle cell lymphoma (MCL), hairy cell leukemia, plasmacytoma, and small T-cell proliferations.
Although a number of B-cell lymphoproliferative processes (either primary splenic or secondary involvement) were considered in the differential diagnosis, including chronic lymphocytic leukemia/small lymphocytic lymphoma, mantle cell lymphoma, lymphoplasmacytoid lymphoma (immunocytoma), follicular lymphoma, extranodal marginal zone lymphoma, and hairy cell leukemia, the histologic findings as well as immunophenotypic analysis were felt to be most in keeping with a splenic marginal zone B-cell lymphoma.
Splenic lymphoma with villous lymphocytes (SLVL) and hairy cell leukemia (HCL) are similar-appearing B-cell neoplasms with cytoplasmic projections.