hairy cell


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hairy cell

(hâr′ē)
n.
A white blood cell having multiple surface projections and characteristically present in hairy cell leukemia.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
Haematology A round or ovoid, 12–20-µm peripheral blood cell characterised by filamentous projections that are fine/hairy by phase contrast and electron microscopy, but thick or smudged and irregular by light microscopy; hairy cells are monotonously uniform in appearance; the nucleus is ovoid and may be indented, and usually central, but may be eccentric with 1+ nucleoli; the chromatin is fine or slightly coarse; the moderate amount of cytoplasm stains pale blue; N:C ratio is 4:1 to 2:1
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

hair·y cell

(hār'ē sel)
Medium-sized leukocytes that have features of reticuloendothelial cells and multiple cytoplasmic projections (hairs) on the cell surface, but may be a variety of B lymphocyte; found in hairy cell leukemia.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
The global hairy cell leukemia therapeutics market has been witnessing some advances in research since the beginning of the 21st century, which have led to the launch of a few novel therapies for the treatment of hairy cell leukemia and other hematologic malignancies.
While 2.3% TUNEL-positive inner and outer hairy cells in cochlea cross-sections were observed in the control group, it was 2.6% and 2.5% in the G.
The etiology of HCL is unknown, although a French study that evaluated occupational exposure to pesticides and development of lymphoid neoplasms among men appears to support the hypothesis that occupational pesticide exposures may correlate with development of a number of lymphoid malignancies including hairy cell leukemia, Hodgkin lymphoma, multiple myeloma, and non-Hodgkin lymphoma [12].
* The report provides a snapshot of the global therapeutic landscape of Hairy Cell Leukemia
This was an individual, who, 10 months following treatment with cladribine for hairy cell leukaemia, ended her self-administration of oral contraceptives.
The neoplastic cells stained positive for CD45, CD19, CD20, CD11c, CD22, CD25, and CD103, consistent with hairy cell leukemia.
A blood smear showed 10% hairy cells, and a bone marrow biopsy confirmed a diagnosis of hairy cell leukemia and interstitial infiltration of CD20-positive, monoclonal antibody DBA.44-positive, and tartrate-resistant acid phosphatase-positive cells.
Although the etiology of paraneoplastic vasculitis is not yet clearly known, suggested mechanisms are: (i) vascular damage caused by cross-reactions between antibodies against tumor cells and the vascular endothelium (ii) vascular inflammation caused by immune complexes involving tumor antigens (iii) direct vascular damage caused by the hairy cells in hairy cell leukemia.
However, the gene expression profile of the icukemic cells is not the same as that of the normal counterpart and displays many similarities and differences (7), (24-27) Gene expression profile of the leukemic B cells in fbllicular lymphorna, hairy cell leukemia and CLL has been shown to resemble the germinal center or the memory stage of differentiati on (7), (24), (28), (29).