Pyrosequencing of BRAF V600E in routine samples of hairy cell
leukaemia identifies CD5+ variant hairy cell
leukaemia that lacks V600E.
of Cases (%) Cryptosporidial diarrhea(C parvum) 4(4) Cryptococcal meningitis 15(14) Tuberculosis: (i) Extrapulmonary 16(15) (ii) Pulmonary 24(23) Pneumocystis carinii pneumonia(PCP) 3(3) Cerebral toxoplasmosis 5(5) Penicillium marneffei 5(5) Herpes zoster 14(14) Viral meningitis 2(2) Oral candidiasis 22(21) Hepatitis B virus 11(11) Hepatitis C virus 24(23) Cytomegalovirus infection (CMV) 2(2) Kaposis's sarcoma 1(1) Hairy cell
leukoplakia 1(1) Table 5: Distribution of HIV seropositive cases with respect to associated diseases Associated Diseases No.
leukemia expresses bright pan-B-cell antigens and, uniquely among B-cell neoplasms, strongly expresses CD11c, CD25, CD103, CD123, and annexin A1 typical ly.
One of 4 LPL/WM cases (25%) and 1 of 3 hairy cell
leukemia cases (33%) showed a heterogeneous positive pattern, whereas the remaining cases showed a homogeneous negative pattern (Table 1).
Topics that will be discussed include B-cell small lymphocytic lymphoma/leukemia, lymphoplasmacytic lymphoma, extranodal marginal zone (MALT) lymphoma, follicular lymphoma, mantle cell lymphoma (MCL), hairy cell
leukemia, plasmacytoma, and small T-cell proliferations.
Although a number of B-cell lymphoproliferative processes (either primary splenic or secondary involvement) were considered in the differential diagnosis, including chronic lymphocytic leukemia/small lymphocytic lymphoma, mantle cell lymphoma, lymphoplasmacytoid lymphoma (immunocytoma), follicular lymphoma, extranodal marginal zone lymphoma, and hairy cell
leukemia, the histologic findings as well as immunophenotypic analysis were felt to be most in keeping with a splenic marginal zone B-cell lymphoma.
Splenic lymphoma with villous lymphocytes (SLVL) and hairy cell
leukemia (HCL) are similar-appearing B-cell neoplasms with cytoplasmic projections.