The kinocilia are arranged in one continuous row per hair cell
, which suggests response polarity and is consistent with a standard pattern for healthy hair cells
in the squid statocyst (Budelmann et al., 1973).
In their latest work, the investigators found that blocking the Notch pathway increases the formation of new hair cells
not from remaining hair cells
but from certain nearby supporting cells that express a protein called Lgr5.
Selective inner hair cell
loss in premature infants and cochlea pathological patterns from neonatal intensive care unit autopsies.
The hair cell
needed the gel-like capsule--called the cupula--to overcome these challenges.
Rescue of hearing, auditory hair cells
, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation.
Figures 2A, B and C show activity in three different nerve fibers attached to hair cells
at three different cochlear locations.
"Eight weeks after treatment, we found new auditory hair cells
in the Atohl-treated ears of the research animals," reports Dr.
Simultaneous exposure to ethyl benzene and noise: synergistic effects on outer hair cells
. Hear Res 162(12):67-79.
US researchers, reporting in the journal Science, say that this demonstrated that it was a direct effect of the Rb1 gene that prevented hair cell
regeneration and not an indirect consequence of development.
The tiny hair cells
in the inner ear can become damaged from the strong vibrations or from too much "wear and tear" on them.
"Inside the cochlea, there are little hair cells
that bend, sending an electrical current up the hearing nerve," he explained.
At the same time, the tiny hair cells
within the vestibular system are becoming less sensitive to head motion, diminishing the response of the ocular reflex that stabilizes your eyes.