Two distinct anticoagulant drugs were utilized to investigate the haemostatic effects of ABS, warfarin and heparin.
Therefore, ABS was used as a local haemostatic agent to control warfarin and heparin-induced bleeding in present study.
Ankaferd blood stopper is a unique standardized herbal mixture being used as a haemostatic agent in Turkey for many years.
(16) also demonstrated that ABS had a haemostatic effect on the cut tails of rats alone or in the presence of heparin or aspirin medication.
In addition the previous result of the present study, ABS should be used on warfarin models as a local haemostatic agent due to statistically significance between Warfarin group, Control group, and Warfarin-Ankaferd group in terms of bleeding time and amounts (p<0.05).
According to the aforementioned criteria, an ideal haemostatic material should have no negative impact on the fresh wound (site of topical application) and its healing process .
Because of some previously poor experiences regarding the use of haemostatic products, their safety for human tissues remains a constant concern .
Another limitation of the current work was not comparing the impact of zeolite-bentonite powder on wound healing to that of an FDA-approved haemostatic agent to which we had no access.
In conclusion, according to this stereological study, onetime topical usage of zeolite-bentonite haemostatic powder on an animal skin wound could negatively affect the healing process by inhibition of neovascularization and vasoconstriction.
Bloch, "Haemostatic dressings in prehospital care," Emergency Medicine Journal, vol.