haemolytic-uraemic syndrome

haemolytic-uraemic syndrome (HUS)

The combination acute kidney insufficiency, haemolytic anaemia and a low platelet count (thrombocytopenia). Biopsy of kidney tissue shows a blood vessel disorder with thrombosis of the glomerular and other small vessels. In spite of the thrombocytopenia, blood clotting times are normal. The syndrome has many causes including Shiga toxin-producing E. coli infection in post-diarrhoea cases, other infections, pregnancy, drugs, cancers, systemic lupus erythematosus and organ transplants, but most probably relate ultimately to endothelial injury. Its effects may be very serious as almost any system of the body may be involved.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Escherichia coli cytotoxin, haemolytic-uraemic syndrome, and haemorrhagic colitis.
Sporadic cases of haemolytic-uraemic syndrome associated with faecal cytotoxin and cytotoxin-producing Escherichia coli in stools.
Acute neurology and neurophysiology of haemolytic-uraemic syndrome. Arch.
Haemolytic-uraemic syndrome (HUS) is an important cause of acute kidney injury (AKI) in children, leading to significant morbidity and mortality, and the effects of which may persist into adulthood.
urea (mg/dl) (mg/dl) 1 86 2.0 2 100 2.1 3 88 2.3 4 88 7.2 5 177 5.8 6 176 5.3 7 118 2.9 8 167 6.3 9 173 3.8 D-HUS = haemolytic-uraemic syndrome occurring without a diarrhoeal prodrome; BP = blood pressure; Hb = haemoglobin; WBC = total white blood cell count; Platelet = platelet count; S-LDH = serum lactate dehydrogenase; C3 = component 3; S-Cr = serum creatinine; F = female; M = male.
Haemolytic-uraemic syndrome (HUS) is the most frequent cause of acute renal failure in childhood [1].
She later developed the most severe form of EHEC infection, haemolytic-uraemic syndrome, in which the kidneys and nervous system fail and patients often suffer epileptic fits.
The infection can cause the deadly complication - haemolytic-uraemic syndrome (HUS) - affecting the blood and kidneys.
Haemolytic-uraemic syndrome in childhood: surveillance and case-control studies in Italy.