A diagnostic approach in a patient with a suspected
haemoglobinopathy requires a thorough history and clinical examination, directed laboratory testing including family studies, and an accurate interpretation of the results.
The lower levels of HbE compared to other P-chain structural variants could be attributed to HbE being a thalassaemic
haemoglobinopathy with unstable m-RNA (16).
Malaria,
haemoglobinopathy and G6PD deficiency are common in Indo-China.
We conclude that an anaesthetist should be alerted to the diagnosis of
haemoglobinopathy in a patient whose cyanosis does not improve even on adequate ventilation with 100% oxygen.
Wild PhD FIBMS Clinical Scientist
Haemoglobinopathy Genetics Centre University College Hospitals London NHS Foundation Trust London
Beta-thalassaemia is a common
haemoglobinopathy in India as per WHO records.
On the basis of results, we propose an extended alpha thalassemia genetic mutation panel should be used for screening of children presenting with anemia with suspicion of
haemoglobinopathy.
There was no sign of haematological abnormalities such as a
haemoglobinopathy or leukaemia.
7] Haematological alterations associated with malaria are well recognised, but specific changes may vary with the level of malaria endemicity and patient background,
haemoglobinopathy, nutritional status, demographic factors and malaria immunity.
Contract notice: Managed Pathology Laboratory Service Contract for the provision of clinical chemistry and immunochemistry, immunology, bacterology and infectious serology, coagulopathy,
haemoglobinopathy, Point of Care testing, Molecular Biology, and HbA1c testing and the associated automation /items/ services, reagents and consumables, maintenance, enabling works for the above disciplines for Homerton University Hospital NHS Foundation Trust.
Staff from Slater & Gordon were given two hours to turn the
haemoglobinopathy ward into a winter wonderland.
Along with colleagues from Crown Worldwide Group, Paul Rowntree surprised children in the
haemoglobinopathy unit with a visit to decorate their ward for Christmas.
