haemoglobin


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haemoglobin

he·mo·glo·bin

(Hgb, Hb) (hē'mō-glō'bin)
The red respiratory protein of erythrocytes, consisting of approximately 3.8% heme and 96.2% globin, with a molecular weight of 64,450, which as oxyhemoglobin (HbO2) transports oxygen from the lungs to the tissues where the oxygen is readily released and HbO2 becomes Hb. When Hb is exposed to certain chemicals, its normal respiratory function is blocked; thus, oxygen in HbO2 is easily displaced by carbon monoxide, a process that results in the formation of fairly stable carboxyhemoglobin (HbCO), as in asphyxiation resulting from inhalation of exhaust fumes from gasoline engines. When the iron in Hb is oxidized from the ferrous to ferric state, as in poisoning with nitrates and certain other chemicals, a nonrespiratory compound, methemoglobin (MetHb), is formed.
Synonym(s): haemoglobin.

haemoglobin

The iron-containing protein that fills red blood cells. Haemoglobin combines readily but loosely with oxygen in conditions of high oxygen concentration, as in the lungs, and releases it when in an environment low in oxygen, as in the body tissues. In health, each 100 ml of blood contains 12–18 g of haemoglobin. The various genetically induced abnormalities of haemoglobin are called HAEMOGLOBINOPATHIES.

haemoglobin

a large PROTEIN molecule with a quaternary structure of four POLYPEPTIDES CHAINS, two alpha and two beta chains, each of which is complexed to a separate HAEM group. About 300 million molecules of haemoglobin occur in each red blood cell of the mammalian circulation, with each molecule binding to a maximum of four oxygen molecules, one per haem group (= oxygenation). See OXYGEN-DISSOCIATION CURVE for an explanation of oxygen carriage. Haemoglobin is found in all vertebrates and many invertebrates. In mammals the foetal haemoglobin (HbF) has a different polypeptide combination from that in postnatal ‘adult’ haemoglobin (HbA), consisting of two alpha and two gamma chains, with different oxygen-carrying characteristics (up to 30% more at low oxygen tension). An altered beta chain in HbA produces SICKLE-CELL ANAEMIA.

haemoglobin

the iron-containing protein with the property of binding oxygen, contained in red blood cells. See also oxyhaemoglobin dissociation curve.

haemoglobin

; Hb red-coloured protein within erythrocytes (6% haem; 94% globin); transports oxygen (as oxyhaemoglobin) from lungs to tissues, where oxygen is readily given up and oxyhaemoglobin is reduced to haemoglobin (see glycosylated haemoglobin)

he·mo·glo·bin

(Hb) (hē'mō-glō'bin) [MIM*141800142310, MIM*141800]
Red respiratory protein of erythrocytes. In humans, there are at least five kinds of normal Hb: two embryonic Hbs (Hb Gower-1, Hb Gower-2), fetal (Hb F), and two adult types (Hb A, Hb A2).
Synonym(s): haemoglobin.

Patient discussion about haemoglobin

Q. haemoglobin deficiency Haemoglobin deficiency - 6.3 rbc count less than normal range. platelets are 157000

A. what you describe here is pretty harsh numbers. very very low hemoglobin, low platelets level...have you checked for white blood cells? i recommend seeing a Dr. ASAP. with these numbers there is a good chance that you'll bleed from places that are not supposed to bleed.

More discussions about haemoglobin
References in periodicals archive ?
In 1950, itano identified the haemoglobin D as a new variant.
Fluctuations in haemoglobin levels in haemodialysis patients receiving intravenous epoetin alfa or intravenous darbepoetin alfa.
The bacterium obtains iron by extracting it from haemoglobin.
The haemoglobin polymer carries oxygen in the plasma in a similar manner to normal red cell haemoglobin, i.
The authors did a meta-analysis of randomised controlled clinical trials, using trials that assessed the effects of targeting different haemoglobin concentration in patients with anaemia caused by chronic disease who were randomly assigned to treatment with recombinant EPO.
Oxygen-binding characteristics of three extracellular haemoglobins of Artemia salina.
The atlas section comprises 170 full colour pages in which each variant haemoglobin or combination of haemoglobins is illustrated by cellulose acetate electrophoresis at alkaline pH, agarose gel electrophoresis at acid pH, isoelectric focusing and one or more HPLC traces.
Keywords: Haemoglobin J variant, -globin gene, Rare mutation, Northern Iran.
TMPRSS6's role was identified as part of a genome-wide association study, carried out by scientists from Imperial College London, which looked at the link between genes and haemoglobin level in 16,000 people.
THE simple haemoglobin HbA1c test shows the average amount of sugar in your blood over the last two to three months.
Validity of the haemoglobin colour scale in blood donor screening.