Other known causes of anaemia in HF include iron deficiency, renal insufficiency, haemodilution
due to activation of renin-angiotensin-aldosterone and vasopressin systems, infections such as HIV, and drugs that interfere with the synthesis of endogenous erythropoietin, e.g.
Two-thirds of respondents no longer support the routine combined use of hypervolaemia, haemodilution
and hypertension (Triple H therapy).
The effect of retrograde autologous priming volume on haemodilution
and transfusion requirements during cardiac surgery.
Several factors cause a more profound systemic inflammatory response in neonates and infants compared to older children or adults: (1) the surface and the volume of the CPB circuit relative to the blood volume and patient size, (2) more frequent use of hypothermic circulatory arrest, and (3) more pronounced haemodilution
Initially decreased viscosity after haemodilution
improves venous return and cardiac preload, thereby increasing cardiac output.
Briefly, the current recommendations entail that the patient should abstain from foods and beverages for at least 6-12 hours before testing (8), in order to limit the unwanted effects of food ingestion and haemodilution
on a number of laboratory analytes (9-11).
The authors observed that in the subjects demonstrating an increase in Hbmass, isovolumic haemodilution
elicited a 5.8% decrease in [VO.sub.2max].
Secondly, all patients had suffered multiple injuries and had typically received transfusion of fluids not containing Mg, causing haemodilution
, and would typically have high serum catecholamine levels, which have been shown to cause Mg shift to the intracellular space.
In addition, haemodilution
in the later stages of gestation and the way it modulates blood folate should be taken into consideration [1, 2, 7].
The mechanism is unclear, but some reports suggest that it could be explained by an increase in the unbound propofol after aggressive haemodilution
This finding suggests the postoperative reduction in haemoglobin levels observed is representative of haemodilution
rather than blood loss during surgery [12,13].
Wilhelm et al., "Bovine haemoglobin is more potent than autologous red blood cells in restoring muscular tissue oxygenation after profound isovolaemic haemodilution
in dogs," Canadian Journal of Anaesthesia, vol.