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Specifically expressed in keratinizing squamous epithelia, HSCCE is suggested to play a role in the turnover and/or formation of the stratum corneum (2).
Because the HSCCE gene (a) is located next to other members in the human kallikrein family, (b) has the same genomic organization and intron phase as other members of this family and (c) has significant homology to other members of the family in both the DNA and amino acid sequences (7), HSCCE is now considered to be a member of the human kallikrein family and has been given a new name, KLK7 for the gene and human kallikrein 7 (hK7) for the protein (8).
a) Official Name when first First GenBank First kallikrein cloned submission publication name KLK4 Prostase AF113141 (24) KLK5 KLK-L2 AF135028 (23) KLK6 Neurosin D78203 (mRNA) (73) AF149289 (Full gene) (22) KLK7 HSCCE (b) L33404 (mRNA) (74) AF166330 (Full gene) (13) KLKS Neuropsin AB009849 (75) KLK9 KLK-L3 AF135026 (76) KLK10 NES1 NM 002776 (mRNA) (58) AF055481 (Full gene) (77) KLK11 TLSP ABO12917 (mRNA) (78) AF164623 (Full gene) (79) KLK12 KLK-L5 AF135025 (28) KLK13 KLK-L4 AF135024 (14) KLK14 KLK-L6 AF161221 (27) KLK15 KLK15 AF242195 (7) (a) A brief history describing the discovery of the three classic kallikreins has been published in a recent review (54).
New gene Previous gene New protein symbol (a,b) symbol(s) symbol KLK1 KLK1 hK1 KLK3 KLK3 hK3 KLK2 KLK2 hK2 KLK4 PRSS17, KLK-L1, KLK4 hK4 KLK5 KLK-L2 hK5 KLK6 PRSS9 hK6 KLK7 PRSS6 hK7 KLKS PRSS19 hK8 KLK9 KLK-L3 hK9 KLK10 PRSSL1, hK10 KLK11 PRSS20 hK11 KLK12 KLK-L5 hK12 KLK13 KLK-L4 hK13 KLK14 KLK-L6 hK14 New gene symbol (a,b) Other protein names/symbols KLK1 Pancreatic/renal kallikrein, hPRK KLK3 Prostate-specific antigen, PSA KLK2 Human glandular kallikrein 1, hGK-1 KLK4 Prostase, KLK-L1 protein, EMSP1 KLK5 KLK-L2 protein, HSCTE KLK6 Zyme, protease M, neurosin KLK7 HSCCE KLKS Neuropsin, ovasin, TADG-14 KLK9 KLK-L3 protein KLK10 NES1 protein KLK11 TLSP/hippostasin KLK12 KLK-L5 protein KLK13 KLK-L4 protein KLK14 KLK-L6 protein New gene GenBank symbol (a,b) Accession No.
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