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Plural of gutta.
Farlex Partner Medical Dictionary © Farlex 2012
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On the slit lamp, FED can be identified by endothelial guttae seen using specular illumination.
Central endothelial guttae are an initial manifestation of FED and the dystrophy may or may not be symptomatic.
The debilitating symptom of glare due to confluent guttae with pigment can occur even when there is little or no stromal oedema and pachymetry is relatively normal (<600[micro]m).
FECD affects approximately 4% of the population in the fourth or fifth decade of life and is characterized by an accelerated decrease of postmitotic endothelial cells density caused by apoptosis, as well as formation of posterior excrescences of Descemet's membrane, termed guttae, which arise as abnormal accumulation of subendothelial deposition of profibrotic extracellular matrix [23, 24].
Not only are the genetic defects better defined, but also patient's corneas show specific histopathological patterns including greater Descemet's membrane thickening and types of guttae. Inherited in a clear autosomal dominant pattern without any sex-difference, patients often become symptomatic in their 20s or 30s.
Guttae (from the Latin gutta for 'drop') on the corneal endothelium are the characteristic first sign of FCED.
On eye examination, the presence of guttae, corneal oedema and, later on, epithelial bullae indicates the presence of Fuchs\' endothelial corneal dystrophy.
Fuchs' endothelial corneal dystrophy (FECD), first described by Austrian ophthalmologist Ernst Fuchs [1], is a slowly progressing corneal disorder, characterizing as cornea guttae on the thickened Descemet's membrane (DM), generalized corneal edema, and decreased visual acuity.
Clinically, FECD can be diagnosed by dew-drops like central glittering brown corneal guttae in slit lamp biomicroscopy [7, 10] in conjunction with increased corneal thickness in pachymetry, decreased endothelial cell counts in specular microscopy, and hyporeflective areas representing guttae in endothelial background in confocal biomicroscopy [11].
Guttae preparations should be prescribed for daytime and a lubricant gel or ointment can be used at night.
She has been using guttae Dorzolamide 2% twice daily, Brimonidine tartrate 0.1% twice daily, and Latanoprost 0.005% nocte in both eyes during this time.