T1R2 and T1R3 are expressed in pancreatic [beta]-cells; inhibition of this receptor by gurmarin
or deletion of the T1R3 gene attenuates glucose-induced insulin secretion from [beta]-cells [9, 13].
[14,15] The phytoconstituents such as gymnemic acid, gymnema saponins, and gurmarin
are responsible for sweet suppression activity.
Our research inquire about to determine if bitter melon inhibit growth on cancer cells, It contains Gurmarin
, a polypeptide similar to bovine insulin, which shows a positive sugar regulating effect by suppressing the neural response to sweet taste stimuli.