- The approved drugs in the IBS space target chloride channel 2, calcium channel, serotonin 5-HT3 receptor, guanylyl
cyclase c receptor, opioid receptors, gram-negative bacteria, and RNA polymerase.
In pancreatic cells, STZ has the ability to act as NO donor (Som et al, 2001), which prevents mitochondrial matrix aconitase activity, leading to DNA alkylation and damage increases the activity of guanylyl
cyclase and the formation of cGMP, which are characteristic actions of NO.
It is a guanylyl
cyclase which is an enzyme that synthesizes the important messenger cGMP.
A phase II study of antibody-drug conjugate, TAK-264 (MLN0264) in previously treated patients with advanced or metastatic pancreatic adenocarcinoma expressing guanylyl
In vascular smooth muscle cells, superoxide inhibits the activity of enzymes such as guanylyl
cyclase  and cGMP dependent kinase protein,  thereby reducing endothelium-induced and NO-dependent vasodilatation.
Effects of elevated ecdysteroid on tissue expression of three guanylyl
cyclases in the tropical land crab Gecarcinus lateralis: possible roles of neuropeptide signaling in the molting gland.
Nitric oxide (NO) is an EDRF that induces the relaxation of smooth muscles in blood vessels through guanylyl
cyclase/cyclic guanosine monophosphate (sGC/cGMP).
C-type natriuretic peptide increases myocardial contractility and sinus rate mediated by guanylyl
cyclase-linked natriuretic peptide receptors in isolated, blood-perfused dog heart preparations.
Nitric oxide synthase (NOS), nitric oxide (NO), soluble guanylyl
cyclase (sGC) and cyclic guanosine monophosphate (cGMP) have major roles in penile erection physiology.
In addition to this antimicrobial activity, NO also activates protein kinase G (PKG) and guanylyl
cyclase to directly speed up ciliary beat frequency (CBF), increasing mucociliary clearance (Figure 1) .
It was discovered that CO is a weak activator of guanylyl
cyclase (GC) thus allowing CO to effect smooth muscle relaxation and potentially block platelet aggregation.
Krawczyk et al., "Hypertension reduces soluble guanylyl
cyclase expression in the mouse aorta via the Notch signaling pathway," Scientific Reports, vol.