1978) Mechanism of cholera toxin action: Covalent modification of the guanyl
nucleotide-binding protein of the adenylate cyclase system.
Endogenous biologically active human parathyroid hormone: measurement by a guanyl
nucleotide-amplified renal adenylate cyclase assay.
4), (5) Various intermediates have been isolated, and they include the products of structural rearrangement of the imino esters into 2-oxazolidones and guanyl
ureas, (6), (7) The reactivity of DICY can be influenced by the presence of solvent, the formation of a zinc complex with zinc, and the presence of proton-donating entities.
The plug and rod membrane accumulates abundant amounts of cyclic guanosine monophosphate (cGMP), synthesized by the enzyme guanyl
Nitric oxide causes an activation of guanyl
cyclase and an increase in cyclic guanine monophosphate, which mediates the relaxation of vascular smooth muscles.
T cells contain two types of Ras activators: a molecule called SOS and another called Ras guanyl
nucleotidereleasing protein, or RasGRP.
That protein is termed a "G-protein" because of the fact that its enzymatic activity is determined by its binding to a guanyl
nucleotide: it is active when bound to GTP (guanosine triphosphate) from the cytoplasm but inactive when bound to GDP.
1 mM, NO-sintasa inhibitor), methylene blue (1 [micro]M, guanyl
ciclasa inhibitor), glibenclamide (1 [micron]M, [K.
Binding of the NPs to NPR-A and -B stimulates intrinsic guanyl
cyclase activity and the production of the intracellular messenger, cGMP.
ca Abbreviations: D-NAME, D-nitroarginine-methyl-ester; GA, geldanamycin; GBD, geldanamycin binding domain; HSP90, heat shock protein 90; L-NAME, L-nitroarginine-methyl-ester; NO, nitric oxide; NOS, nitric oxide synthase; ODQ, IH-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; RD, radicicol; sGC, soluble guanyl
cyclase; SNAP, S-nitroso-N-acetylpenicillamine.
Role of fluidity of membranes on the guanyl
nucleotide-dependent binding of cholecystokinin 8-S to rat brain cortical membranes.
All muscarinic receptors are coupled to guanyl
proteins that determine the specificity of their actions.