The radical of guanine.
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NO activates the soluble guanyl cyclase, subsequently leading to the production of cGMP.
Extracellular FFA activate PKC and impair insulin-mediated activation of PI3K thus reducing the bioavailability of NO, the intracellular vasodilator which keeps the endothelium-dependent vasorelaxation by stimulation of guanyl cyclase and increment of intracellular levels of cyclic guanine monophosphate (cGMP) [36].
Unlike pyrimidine specific RNases thatbelong to the family of RNase A (EC, RNases T1 are guanyl specific; hence, 2',3'-cyclic guanosine monophosphate (2',3'-cGMP) can only be cleaved in the second step of catalysis [1].
Combination Effect of Guanyl Acid/Vitamin [D.sub.2] with PCPS on Proinflammatory Cytokine Secretion from the Stimulated Macrophages.
PDE activity is tightly coupled with the activity of adenyl cyclases (AC) and guanyl (GC) which synthesize these cyclic nucleotides: cAMP and cGMP.
Enhancement of choleragen ADP-ribosyltransferase activities by guanyl nucleotides and a 19-kDa membrane protein.
Differential regulation of [alpha]1- and [alpha]2- adrenergic receptors by guanyl nucleotides and [Na.sup.+]," Molecular Pharmacology, vol.
(1978) Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system.
In normal airway, eNOS present in the healthy epithelia generates low levels of NO to maintain airway tone by activating soluble guanyl cyclase and cGMP production.
Sahoo et al., "Functional screening of cDNA library from a salt tolerant rice genotype Pokkali identifies mannose-1-phosphate guanyl transferase gene (OsMPG1) as a key member of salinity stress response," Plant Molecular Biology, vol.
(4), (5) Various intermediates have been isolated, and they include the products of structural rearrangement of the imino esters into 2-oxazolidones and guanyl ureas, (6), (7) The reactivity of DICY can be influenced by the presence of solvent, the formation of a zinc complex with zinc, and the presence of proton-donating entities.