Chronic inhibition of the sympathetic nervous system with guanethidine
: effects on body and organ weights and food intake of chicks given a phenylalanine excess diet.
The effect of guanethidine
and local anesthetics on the electrically stimulated mouse vas deferens.
if added to Lignocaine produces prolonged hypotension, apnoea, and angina.
Animals received bilateral vagotomy, the sympathetic adrenergic blocker guanethidine
, or the muscarinic (parasympathetic) antagonist atropine after exposure to either FA or wDE (30 min before aconitine challenge).
(8) An RCT of IV guanethidine
found no benefit compared with saline.
Effect of guanethidine
on dopamine in small intensily fluorescent cells of the superior ganglion of the rat.
Other common drugs that can provoke similar symptoms are aspirin, nonsteroidal anti-inflammatory drugs, beta blockers (oral and ophthalmic), bromocriptine, estrogens, oral contraceptives, prazosin, methyladopa, phentolamine, guanethidine
, reserpine, and tricyclic antidepressants.
. New England Journal of Medicine, 295, 1053.
Amitriptyline and imipramine may decrease or reverse effects of clonidine and guanethidine
and may increase the effects of central nervous system depressants, adrenergic agents, and anticholinergic agents.
For example, a few years ago, a 40-year-old obese, hypertensive, diabetic woman was scheduled to undergo arthroscopic knee surgery under general anesthesia.(10) For a considerable period of time pre-operatively she had been taking chlorothiazide, furosemide and guanethidine
. She remained on these medications at the time of the operation.
Hannington-Kiff, Relief of Causalgia in Limbs by Regional Intravenous Guanethidine
, 1979-2 BRIT.