Clonidine (Catapres) or guanabenz
(Wytensin) may produce severe dryness' of the mouth, constipation or drowsiness.
In contrast, among the imidazoline and guanidine agonists (rank order potency was dexmedetomidine > oxymetazoline > clonidine > UK-14303 and guanabenz
> guanfacine, respectively, see figures below), only UK-14303 was a full agonist.
Traces of Guanabenz and 16b Hydroxy-Stanozol showed up in the endurance horses during postcompetition checks conducted by Sheikh Mohammed's staff in the United Arab Emirates last week, following two races in the country.
Guanabenz is used to treat high blood pressure in people, common side effects being dizziness, drowsiness, dry mouth, headache and weakness.
4,12] It is prudent to weigh these risk factors when considering initiating or increasing clonidine therapy, or when using other centrally acting alpha-2 receptor agonists, such as guanabenz
and guanfacine, which may cause the same effect.
38] Clonidine and guanabenz
are two centrally acting [alpha]-adrenergic agonists for which only limited data on their lipid-modifying potential are available.