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In contrast to multiple sclerosis, guanabenz treatment in rodent models of CNS injuries showed contradictory effects.
Sephin1 is a guanabenz derivative with selective inhibitory effect on stress-induced dephosphorylation of eIF2[alpha] by the GADD34:PP1 complex (Figure 2), without [alpha]2-adrenergic activity [42].
Avery, "Guanabenz: a review of its pharmacodynamic properties and therapeutic efficacy in hypertension," Drugs, vol.
Clonidine (Catapres) or guanabenz (Wytensin) may produce severe dryness' of the mouth, constipation or drowsiness.
"Additionally, although endurance is not an Olympic discipline, but in view of her position as a member of the International Olympic Committee [IOC], Princess Haya immediately notified the IOC Ethics Commission of her decision to defer presidency of the FEI in this matter." Guanabenz is used to treat high blood pressure in people, common side effects being dizziness, drowsiness, dry mouth, headache and weakness.
For refractory symptomatic cases, isoproterenol, epinephrine, dopamine, and pacing can be considered.[4,12] It is prudent to weigh these risk factors when considering initiating or increasing clonidine therapy,[8] or when using other centrally acting alpha-2 receptor agonists, such as guanabenz and guanfacine, which may cause the same effect.[21,22] This should include taking a thorough cardiac and medication history and possibly obtaining renal function tests and an ECFG if the history indicates potential problems.[9] When following a patient on clonidine, the patient's pulse rate and blood pressure should be checked.[9] Clonidine should be used with caution in a patient with known sinus node dysfunction,[19] and patients with renal impairment should be considered for reduced dosages.
The centrally acting agents, such as methyldopa and clonidine, effectively lower blood pressure, but data on their effect on lipids and lipoproteins are somewhat conflicting (Table 4).[44] Methyldopa has been shown to decrease high-density lipoprotein cholesterol levels and increase the ratio of total cholesterol to high-density lipoprotein cholesterol.[38] Clonidine and guanabenz are two centrally acting [alpha]-adrenergic agonists for which only limited data on their lipid-modifying potential are available.
Effect of Centrally Acting Antihypertensive Drugs, Angiotensin-Converting Enzyme Inhibitors, and Calcium Channel Blockers on Blood Lipids Mean Change, Drug Lipid Component % Guanabenz Total cholesterol [arrow down] 7 LDL cholesterol [arrow down] 14 Clonidine Total cholesterol [arrow down] 8 Methyldopa HDL cholesterol [arrow down] 14 Total/HDL cholesterol ratio [arrow up] 19 Captopril Total cholesterol NC Total triglycerides NC HDL cholesterol NC Nifedipine Total cholesterol NC Total triglycerides NC LDL, VLDL cholesterol NC HDL cholesterol NC Diltiazem HDL cholesterol [arrow up] 15 Total/HDL cholesterol ratio [arrow down] 11 LDL denotes low-density lipoprotein; HDL, high-density lipoprotein; VLDL, very low-density lipoprotein, NC, no change.