guaifenesin


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expectorant

 [ek-spek´to-rant]
1. promoting expectoration.
2. an agent that so acts.
liquefying expectorant an expectorant that promotes the ejection of mucus from the respiratory tract by decreasing its viscosity.

guaifenesin (glyceryl guaiacolate)

Balminil Expectorant (CA), Benilyn Childrens Chesty Coughs (UK), Benylin-E (CA), Calmylin Expectorant (CA), Diabetic Tussin EX, Genatuss, Koffex Expectorant (CA), Mucinex, Organidin NR, Phanacin XPECT, Pneumomist, Resyl (CA), Robitussin, Robitussin Chesty Cough (UK), Scot-tussin Expectorant, Siltussin SA, Tixylix Chesty Cough (UK), Venos for Kids (UK), Vicks Vaposyrup for Chesty Coughs (UK)

Pharmacologic class: Propanediol derivative

Therapeutic class: Expectorant

Pregnancy risk category C

Action

Exerts vasoconstrictive action that leads to decreased edema and congestion. Also increases respiratory secretions and reduces mucus viscosity.

Availability

Capsules: 200 mg

Oral solution: 100 mg/5 ml, 200 mg/5 ml

Syrup: 100 mg/5 ml

Tablets: 100 mg, 200 mg, 400 mg

Tablets (extended-release): 600 mg

Indications and dosages

Cough due to upper respiratory tract infection

Adults: 200 to 400 mg P.O. q 4 hours (not to exceed 2,400 mg/day), or 600 to 1,200 mg P.O. (extended-release tablets) q 12 hours (not to exceed 2,400 mg/day)

Children ages 6 to 12: 100 to 200 mg P.O. q 4 hours (not to exceed 1,200 mg/day), or 600 mg P.O. (extended-release) q 12 hours (not to exceed 1,200 mg/day)

Children ages 2 to 6: 50 to 100 mg P.O. q 4 hours (not to exceed 600 mg/day)

Contraindications

• Hypersensitivity to drug

• Alcohol intolerance (with some products)

Precautions

Use cautiously in:

• diabetes mellitus, cough lasting more than 1 week or accompanied by fever, rash, or headache

• patients receiving disulfiram concurrently

• pregnant patients.

Administration

• Give with full glass of water.

Adverse reactions

CNS: headache, dizziness

GI: nausea, vomiting, diarrhea, stomach pain

Skin: rash, urticaria

Interactions

Drug-diagnostic tests. Urinary 5-hydroxyindoleacetic acid, vanillylmandelic acid: inaccurate results

Patient monitoring

• Assess cough quality and productivity. Reevaluate treatment if cough persists and is accompanied by fever or headache.

Patient teaching

• Tell patient to take with 8 oz of water and to drink plenty of fluids.

• Instruct patient to contact prescriber if cough lasts more than 1 week.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the tests mentioned above.

guai·fen·e·sin

(gwī-fen'ĕ-sin),
An expectorant that allegedly reduces the viscosity of sputum, thus facilitating its elimination.

guaifenesin

(gwī-fĕn′ə-sĭn)
n.
An expectorant drug, C10H14O4, that is used to thin mucus and sputum.

guaifenesin

Monafed® Common cold An OTC agent for relief of cold/cough. See Common cold.

guai·fen·e·sin

(gwī-fen'ĕ-sin)
An expectorant that allegedly reduces the viscosity of sputum, thus facilitating its elimination.

guai·fen·e·sin

(gwī-fen'ĕ-sin)
An expectorant that allegedly reduces viscosity of sputum, thus facilitating its elimination.
References in periodicals archive ?
According to the companies, the guaifenesin 1200mg extended-release tablets is the OTC store brand equivalent to Mucinex 1200mg extended-release tablets.
"Guaifenesin is in everything, but the doses used in studies [to show efficacy] were much higher than doses used clinically.
Expert opinion: The clinical consultation is important for ruling out ongoing infection and reactive airway disease and for reassuring the patient that the cough will go away Guaifenesin is an expectorant and thus it may be particularly useful for nonproductive cough.
Pharmaceutical company Allergan (NYSE:AGN) and its partner Perrigo Company (NYSE:PRGO) on Monday jointly reported the availability of combination guaifenesin 600mg and pseudoephedrine HCl 60mg extended-release tablets to retail and wholesale customers.
It seems prudent to avoid guaifenesin during the first trimester.
The guaifenesin products are the latest target of an FDA effort, announced in June 2006, to get unapproved, potentially dangerous drugs off the market.
Hycofenix, Mission Pharmacal says, is the first and only combination of hydrocodone, pseudoephedrine and guaifenesin approved by the Food and Drug Administration.
M2 PHARMA-January 5, 2016-Allergan & Perrigo Company unveils guaifenesin 600mg and pseudoephedrine HCl 60mg extended-release tablets for chest congestion to retail and wholesale customers
The companies added that the three Mucinex equivalent products include Mucinex DM Regular Strength (guaifenesin 600mg and dextromethorphan 30mg), Mucinex DM Maximum Strength (guaifenesin 1200mg and dextromethorphan 60mg) as well as Mucinex Maximum Strength (guaifenesin 1200mg)
Maximum Strength Mucinex (1,200 mg guaifenesin extended-release bilayer tablets), Maximum Strength Mucinex DM (1,200 mg guaifenesin/60 mg dextromethorphan HBr extended-release bilayer tablets), and Maximum Strength Mucinex D (1,200 mg guaifenesin/120 mg pseudoephedrine HCl extended-release bilayer tablets) last for 12 hours with the convenience of single tablet dosing.
Codeine, Dextromethorphan, Guaifenesin. There are few studies evaluating the effectiveness of cough medicines that contain combinations of guaifenesin and codeine or dextromethorphan.
Boding well for store brand sales is Allergan pic and partner Perrigo Co.'s approval to market three generics for Mucinex: guaifenesin 600 mg and dextromethorphan 30 mg (Mucinex DM Regular Strength), guaifenesin 1,200 mg and dextromethorphan 60 mg (Mucinex DM Maximum Strength), and guaifenesin 1,200 mg (Mucinex Maximum Strength).