growth hormone deficiency


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growth hormone deficiency

Hypopituitarism Endocrinology A condition which affects 1:4000 children; ♂:♀, 3-4:1 Etiology 70% of GHD is idiopathic and attributed to a prenatal insult, possibly due to hypothalamic dysfunction, given that GHD children secrete hGH after stimulation with GH-releasing hormone; GHD is associated with midline CNS and facial defects–eg, cleft lip and cleft palate; hypopituitarism may be linked to hypotelorism or a single giant upper central incisor; other causes include septooptic dysplasia, craniopharyngioma, intrasellar or suprasellar tumor Clinical Infants with intrauterine hypopituitarism may present at birth with hypoglycemic seizures, prolonged jaundice, and, if ♂, micropenis and undescended testes; linear growth rates as slow as 3 cm/yr; 10% with early onset disease have hypoglycemic seizures; 20% have chemical hypoglycemia; GHD children are proportional for age, have a prominant calvarium, and are often overweight for height, with prominant subcutaneous deposits of abdominal fat; they may have delayed puberty; electrolyte imbalances, diabetes insipidus, hypothyroidism are rare in Pts with idiopathic hypopituitarism; skeletal maturation is usually delayed; most have heights for bone age < third percentile Screening Assessment of bone age, x-rays of sella turcica, measure somatomedin C which, if normal virtually excludes GHD; pituitary function testing–provocative tests: maximal GH <7 ng/ml indicates impaired GH secretion; > 10 ng/ml excludes GHD Management GH replacement typically ↑ growth rate to 8-10 cm in first yr of therapy; treatment failure mandates workup for hypothyroidism or GH antibodies. See Septooptic dysplasia.

Patient discussion about growth hormone deficiency

Q. does the growth hormone have side effects and what are they?

A. Yes, it does, and not a few. They include, among others, pain in the joints, carpal tunnel syndrome, diabetes, pain at the injection site, problems with the thyroid gland, ear problems and many others. You may read more about side effects of growth hormone treatment (called Mecasermin or Somatropin) here: http://www.drugs.com/ppa/mecasermin.html

More discussions about growth hormone deficiency
References in periodicals archive ?
Although children with idiopathic growth hormone deficiency should be retested as they approach adulthood, testing may be unnecessary for those with low insulin-like growth factor-I and known defects, lesions, surgery or radiation of the hypothalamic-pituitary region, or a proven genetic defect in their capacity to secrete growth hormone.
Recurrent hypoglycemia due to growth hormone deficiency in an infant with Turner syndrome.
Pharmstandard offers more than 250 products used in the treatment of diabetes, growth hormone deficiency, cardiovascular diseases, gastroenterological and neurological disorders, infectious diseases and cancer.Country: UkraineSector: PharmaceuticalsTarget: PJSC Pharmstandard-BiolekBuyer: OJSC PharmstandardType: Corporate acquisitionFinancing: Existing resources, CashStatus: Closed
Messi left Newell's Old Boys's youth team in 2000 and moved with his family to Europe, as Barcelona offered treatment for his growth hormone deficiency.
Omnitrope, a somatropin, is approved for long-term treatment of pediatric patients who have growth failure and for long-term replacement therapy in adults with growth hormone deficiency.
In the first category one finds such topics as assessment of growth and puberty, the role of insulin-like growth factors in growth hormone deficiency, characteristics of idiopathic growth hormone deficiency at the start of growth hormone therapy and response to growth hormone, childhood brain tumors and growth hormone treatment, growth hormone treatment of cystic fibrosis, and growth and growth hormone treatment in patients with juvenile idiopathic arthritis, and metabolic effects of growth hormone.
Although children with idiopathic growth hormone deficiency should be retested as they approach adulthood, testing may be unnecessary for those with low insulinlike growth factor-1 and known defects, lesions, surgery or radiation of the hypothalamic-pituitary region, or a proven genetic defect of their capacity to secrete growth hormone.
Endocrine-related causes of short stature include hypothyroidism, cortisol excess, pseudohypoparathyroidism, poorly controlled diabetes mellitus, and growth hormone deficiency. Features associated with these conditions include goiter, dry skin, midline defects, micropenis in boys, and an especially round, cherubic face.
However, growth hormone treatment is approved by the FDA for growth failure in cases of growth hormone deficiency for any reason, as well as for Turner's syndrome, chronic renal insufficiency, PraderWilli syndrome, idiopathic short stature, and children who are small for their gestational age who have not caught up in growth by age 2.
Speke, which employs 460 staff, is Lilly's leading manufacturer of Humatrope, used to treat growth hormone deficiency.
In the meantime, NIH is still providing the hormone to children who have medical problems related to growth hormone deficiency. And a handful of children are receiving genetically engineered hormone manufactured by Genentech in South San Francisco, which is awaiting FDA approval to market the product (SN: 2/11/84, p.
The goal of Ascendis Pharma's Vision 3x3 strategic roadmap through 2025 is to achieve sustainable growth through multiple approaches: Obtain regulatory approval for three endocrinology rare disease products: TransCon hGH for pediatric growth hormone deficiency, TransCon PTH for adult hypoparathyroidism (HP), and TransCon CNP for achondroplasia.

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