growth hormone deficiency


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growth hormone deficiency

Hypopituitarism Endocrinology A condition which affects 1:4000 children; ♂:♀, 3-4:1 Etiology 70% of GHD is idiopathic and attributed to a prenatal insult, possibly due to hypothalamic dysfunction, given that GHD children secrete hGH after stimulation with GH-releasing hormone; GHD is associated with midline CNS and facial defects–eg, cleft lip and cleft palate; hypopituitarism may be linked to hypotelorism or a single giant upper central incisor; other causes include septooptic dysplasia, craniopharyngioma, intrasellar or suprasellar tumor Clinical Infants with intrauterine hypopituitarism may present at birth with hypoglycemic seizures, prolonged jaundice, and, if ♂, micropenis and undescended testes; linear growth rates as slow as 3 cm/yr; 10% with early onset disease have hypoglycemic seizures; 20% have chemical hypoglycemia; GHD children are proportional for age, have a prominant calvarium, and are often overweight for height, with prominant subcutaneous deposits of abdominal fat; they may have delayed puberty; electrolyte imbalances, diabetes insipidus, hypothyroidism are rare in Pts with idiopathic hypopituitarism; skeletal maturation is usually delayed; most have heights for bone age < third percentile Screening Assessment of bone age, x-rays of sella turcica, measure somatomedin C which, if normal virtually excludes GHD; pituitary function testing–provocative tests: maximal GH <7 ng/ml indicates impaired GH secretion; > 10 ng/ml excludes GHD Management GH replacement typically ↑ growth rate to 8-10 cm in first yr of therapy; treatment failure mandates workup for hypothyroidism or GH antibodies. See Septooptic dysplasia.

Patient discussion about growth hormone deficiency

Q. does the growth hormone have side effects and what are they?

A. Yes, it does, and not a few. They include, among others, pain in the joints, carpal tunnel syndrome, diabetes, pain at the injection site, problems with the thyroid gland, ear problems and many others. You may read more about side effects of growth hormone treatment (called Mecasermin or Somatropin) here: http://www.drugs.com/ppa/mecasermin.html

More discussions about growth hormone deficiency
References in periodicals archive ?
Adult growth hormone deficiency assessments have typically been very onerous for doctors and patients alike.
At baseline, those with growth hormone deficiency were a mean of 11 years old; their height was a mean of 2.
1 Causes of short stature can either be normal variants of growth like familial short stature and constitutional delay of growth and puberty(CDGP)2,3 or it can be a result of chronic systemic diseases (renal, pulmonary and cardiac diseases, coeliac disease)4,5 endocrine disorders (hypopituitarism, isolated growth hormone deficiency, isolated hypothyroidism, endogenous and exogenous Cushing syndrome, adrenal insufficiency, osteomalacia or rickets),6-9 genetic (cystic fibrosis),10 chromosomal disorders (Turners syndrome)11 and skeletal dysplasias.
Asia Pacific (APAC) Pen Needles Market, By Product Type (Standard Pen Needles, Safety Pen Needles), By Product Length (Nano Length, Medium Length, Long length), By Usability (Reusable Pen Needles, Disposable Pen Needles), By Application (Diabetes, Growth Hormone Deficiency, Others), By Therapy (Insulin, Glucagon-like peptide-1, Growth Hormones), By End-User (Hospitals, Clinics, OTC, Home Healthcare, Others), By Country (China, India, Japan, South Korea, Singapore, Australia, Rest of APAC) - Trends and Forecast to 2022
The report reviews key players involved in the therapeutics development for Growth Hormone Deficiency and enlists all their major and minor projects
School authorities asked Rajat's parents to enrol him in a special school as he was suffering from growth hormone deficiency
This agreement strengthens Pfizer's commitment to rare diseases, and we are pleased to work with OPKO to help provide a potential next-generation therapy for patients with Adult and Pediatric Growth Hormone Deficiency," said Geno Germano, group president, Pfizer Global Innovative Pharma (GIP).
From a pathology viewpoint, adult human growth hormone deficiency develops from abnormal functioning of the hypothalamus or pituitary gland.
Magnetic resonance imaging in the diagnosis of growth hormone deficiency.
At present, his AGHDA (Adult Growth Hormone Deficiency Assessment) score [7] is 10, so replacement of GH has not been considered yet.
Human growth hormone is a protein, given by injection, that is commonly used to treat children with growth hormone deficiency.
Guidelines for Using Growth Hormone in Paediatric Patients in South Africa: Treatment of Growth Hormone Deficiency and Other Growth Disorders.

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