GRB7(redirected from growth factor receptor-bound protein 7)
GRB7A gene on chromosome 17q12 that encodes an adapter protein which interacts with the cytoplasmic domain of numerous downstream protein kinases (e.g., STAT3, AKT1, MAPK1 and/or MAPK3), activating them. GRB7 promotes activation of HRAS; it plays a role in signal transduction in response to EGF and in regulating cell proliferation and cell migration. It also plays a role in the assembly and stability of RNA stress granules, binding target mRNA molecules and repressing their translation when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery from cellular stress.
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