(redirected from growth differentiation factor 11)

A gene on chromosome 12q13.2 that encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily, which regulate cell growth and differentiation in embryonic and adult tissues. GDF11 is thought to play a role in mesodermal formation and neurogenesis during embryonic development.
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Summary: Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-[beta] (TGF-[beta]) superfamily and acts as a regulator for the aging of multiple tissues.
The study detailed a possible way to reengage a tumor suppressor protein - Growth Differentiation Factor 11, or GDF11, that they found to be inactivated in triple-negative breast cancer cells.
May 9, 2013 -- A new study reveals that a blood hormone known as growth differentiation factor 11 (GDF11) declines with age, and old mice injected with this hormone experience a reversal in signs of cardiac aging.