growing teratoma syndrome

growing teratoma syndrome

A rare condition seen in non-seminomatous germ-cell tumours, which is characterised by enlarging metastatic masses despite appropriate systemic chemotherapy and normalised serum markers.

Management
Interferon is mostly ineffective. Surgery is the cornerstone of therapy and should be performed as soon as possible, as delays can lead to inoperable disease and locally advancing tumours can cause severe renal, biliary, duodenal or large vessel obstruction with bowel necrosis and urinary fistula, potentiating intraoperative and post-operative complications (e.g., ileus, acute pancreatitis, chylous ascites and sepsis).
References in periodicals archive ?
The impression made at this time was either a growing teratoma syndrome or a sarcoma element that was non- responsive to chemotherapy.
As the tumour markers (CA-125, beta-human chorionic gonadotrophin and alpha-fetoprotein) were within the normal range, a working diagnosis of growing teratoma syndrome (GTS) of the ovary was made.
Growing teratoma syndrome as an unusual cause of gliomatosis peritonei: A case report.
Growing teratoma syndrome and peritoneal gliomatosis.
Growing teratoma syndrome of the ovary: Review of literature and first report of a carcinoid tumor arising in a growing teratoma of the ovary.
Carcinoid is seen rarely and review of literature revealed a reported case in a growing teratoma syndrome.
Growing teratoma syndrome is the recurrence of benign mature teratoma tissue after the treatment of immature malignant teratoma.