The protective efficacy of this vaccine, in terms of mortality, clinical signs and gross lesions
, against lethal challenge of virulent IBH-HPS virus was also 100%.
Other patterns of gross lesions
observed in this study were either focally extensive or multifocal and showed histological alterations similarly to the diffuse atrophy of the left lobe; it is likely that these lesions represent an early stage of atrophy.
: No apparent gross lesions
were noticed in any visceral organ of group A (control) birds till the end of study.
The chicks were necropsied to observe gross lesions
and samples of liver, spleen, caecal tonsils, mid-gut and caecal contents, were collected for bacteriology.
A total of 10,389 male and female goats of 2 breeds (West African Dwarf and Red Sokoto) and 1-2 years of age were slaughtered; 1,387 were inspected for gross lesions
No gross lesions
in the pectoral muscles were found in the control pigeons.
In addition to a few nonspecific gross lesions
, nontuberculous lesions were observed in the liver, spleen, and intestinal organs.
Necropsy examination found gross lesions
in the lung, including multifocal to coalescing reddish consolidations, consistent with influenza-induced lung lesions in other species.
(6) Gross lesions
of photosensitization dermatitis consist of erythema and edema and can progress to cutaneous necrosis, vesicle formation, ulceration, exudation, and sloughing of necrotic tissues.
included scattered petechia in epicardial fat within the coronary groove (Figure, panel A), a few petechia in mucosa of the ventriculi (gizzards), slight increase in pericardial fluid, and swollen kidneys.
Eight days after challenge, birds were killed and weighed, and their intestines examined for gross lesions
. Effectiveness of the immunization was measured by analyzing weight gain, intestinal lesions, severity of diarrhea, feed conversion ratio, and oocyst production.
Immunohistochemical analysis with a CCoV-specific monoclonal antibody detected CCoV antigen in the organs with gross lesions
that were examined (lungs, kidneys, liver, spleen, gut, and lymph nodes) (Figure 1).