griseofulvin


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.

gris·e·o·ful·vin

(gris'ē-ō-fŭl'vin),
A fungistatic antibiotic produced by Penicillium griseofulvin, P. patulum, and P. janczewskii; used in the systemic treatment of superficial fungal infections caused by the dermatophytes Microsporum, Trichophyton, and Epidermophyton; inhibits microtubule assembly.

griseofulvin

(grĭz′ē-ə-fŭl′vĭn)
n.
An antibiotic, C17H17ClO6, administered orally for the treatment of ringworm and other fungal infections of the skin, hair, and nails.

griseofulvin

Microbiology An oral antifungal with an affinity for skin, used to treat dermatophytoses–eg, Epidermophyton spp, Microsporum spp, Trichophyton spp Adverse effects Headache, N&V, diarrhea, photosensitivity, fever, rash, dysfunction of hepatic, CNS, hematopoietic systems; it is teratogenic and carcinogenic in rodents. Cf Amphotericin B.

gris·e·o·ful·vin

(gris'ē-ō-ful'vin)
A fungistatic agent used in the systemic treatment of superficial fungal infections caused by certain dermatophytes, which inhibits microtubule assembly.

griseofulvin

An antifungal drug derived from a Penicillium mould that concentrates in the outer layers of the skin and in the nails and is thus useful in the treatment of ‘ringworm’ (TINEA) infections. Skin infections settle quickly, but tinea of the nails requires treatment for months. Brand names are Fulcin and grisovin.

gris·e·o·ful·vin

(gris'ē-ō-ful'vin)
A fungistatic antibiotic produced by Penicillium species; used in systemic treatment of superficial fungal infections.
References in periodicals archive ?
The growth inhibitory effect caused by griseofulvin analogues 5-10 on human breast cancer cell line MCF-7 and human colon cancer cell line HCT116 in comparison to 1, the benzyloxy analogue 3, tamoxifen, and 5-fluorouracil was evaluated using the Sulforhodamine B (SRB) assay after 72-hour exposure.
The treatment interventions were 20 mg/kg fluconazole, 50 mg/kg griseofulvin, 20 mg/kg ketoconazole, 20 mg/kg itraconazole, and 25 mg/kg terbinafine.
3a 500 500 100 500 3b 250 1000 500 1000 3c 500 >1000 250 100 3d 500 100 500 25 3e 12.5 500 1000 500 3f 1000 250 100 100 3g 100 1000 250 250 3'a 500 500 250 250 3'b 500 1000 1000 500 3'c 500 12.5 12.5 100 3'd 1000 500 250 100 3'e 500 12.5 6.25 250 3'f 25 500 >1000 1000 3'g 500 500 250 250 Ciprofloxacin 50 50 25 25 Ampicillin 100 100 250 100 Nystatin -- -- -- -- Griseofulvin -- -- -- -- Antifungal activity Comp (d) C.a A.n.
Nonaka, "Alteration of mRNA levels of S-aminolevulinic acid synthase, ferrochelatase and heme oxygenase-1 in griseofulvin induced protoporphyria mice," Journal of Dermatological Science, vol.
In addition, isolation of cytochalasin J, dechlorogriseofulvin, griseofulvin, demethylharzianicacid, harzianic acid and 2-hexylidene-3methyl-succinic acid from the present study shows that plants from Malaysia rainforest could be hosts to a great diversity of endophytic fungi that serve as a remarkable source of bioactive compounds.
This concern over the decrease in sensitivity of tinea infections to griseofulvin is supported by changes in the initial response and cure rates, and increases in recommendations for dosages and duration of treatment with griseofulvin (Chen & Friedlander, 2001; Roberts & Friedlander, 2005).
Gene expression profiles associated with inflammation, fibrosis, and cholestasis in mouse liver after Griseofulvin. Environ Health Perspect 111:847-853.
Oral contraceptives and combined injectables can generally be used or carry no restrictions for women using griseofulvin. Finally, the tables have been updated to include three new contraceptive methods: patch, ring, and etonogestrel implants.
[Vfend] ketoconazole $3.15 (200 mg) 200-400 mg/day [Nizoral] [$4.30] griseofulvin $2.22 (500 mg) 500-1,000 mg/day [Grifulvin V] [$1.81] [Gris-Peg] [$2.76] flucytosine [$16.16 (250 mg q.i.d.)] 250-500 mg q.i.d.
48-year-old 2002 Vaginitis Iraconazole Cure woman (our case) 36-year-old 1999 Cutaneous Itraconazole Cure man (3) 59-year-old 2001 Cutaneous Itraconazole Cure woman (7) 20-year-old 1977 Cutaneous Griseofulvin Improvement, woman (8) but not cure 19-year-old 1984 Cutaneous Griseofulvin, Improvement man (9) then ketoco- nazole 57-year-old 1999 Lung Surgery Cure man (10) abscess 20-year-old 1972 Pulmonary Amphotericin Cure man (11) effusion B 47-year-old 1980 Sinusitis Surgical Cure woman (12) debridement 34-year-old 1997 Endo- Fluconazole, Progression man (13) phthalmitis ketoconazole, of disease itraconazole 59-year-old 1998 Onychomy- Terbinafine, Progression woman (14) cosis various of disease topical therapies, nail clipping
Taking some anti-HIV or other viral infection treatments, antibiotics tetracycline, ampicillin, rifampicin and griseofulvin, the mood enhancer modafinil and some anti-epileptic drugs can also prevent the pill from working.
Oral terbinafine versus griseofulvin in the treatment of mocassin-type tinea pedis.