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A fungistatic antibiotic produced by Penicillium griseofulvin, P. patulum, and P. janczewskii; used in the systemic treatment of superficial fungal infections caused by the dermatophytes Microsporum, Trichophyton, and Epidermophyton; inhibits microtubule assembly.
griseofulvin/gris·eo·ful·vin/ (gris″e-o-ful´vin) an antibiotic produced by Penicillium griseofulvum ; used as an antifungal in dermatophytoses.
An antibiotic, C17H17ClO6, administered orally for the treatment of ringworm and other fungal infections of the skin, hair, and nails.
indications It is prescribed in the treatment of certain fungal infections of the skin, hair, and nails.
contraindications Liver dysfunction, porphyria, or known hypersensitivity to this drug prohibits its use.
adverse effects The most serious adverse effects are blood dyscrasias. Headache, GI symptoms, and rashes also may occur.
griseofulvinMicrobiology An oral antifungal with an affinity for skin, used to treat dermatophytoses–eg, Epidermophyton spp, Microsporum spp, Trichophyton spp Adverse effects Headache, N&V, diarrhea, photosensitivity, fever, rash, dysfunction of hepatic, CNS, hematopoietic systems; it is teratogenic and carcinogenic in rodents. Cf Amphotericin B.
A fungistatic agent used in the systemic treatment of superficial fungal infections caused by certain dermatophytes, which inhibits microtubule assembly.
griseofulvinAn antifungal drug derived from a Penicillium mould that concentrates in the outer layers of the skin and in the nails and is thus useful in the treatment of ‘ringworm’ (TINEA) infections. Skin infections settle quickly, but tinea of the nails requires treatment for months. Brand names are Fulcin and grisovin.
griseofulvinsystemic antifungal agent used to treat widespread or intractable skin dermatophyte infections and onychomycosis; contraindicated in patients with severe liver disease, systemic lupus erythematosus, porphyria, pregnant and lactating women and infants; use has been largely superseded by newer antifungal agents, e.g. terbinafine; griseofulvin spray (400 µg puffs to a maximum of 1.2 mg/day) is an effective topical treatment for tinea pedis
A fungistatic antibiotic produced by Penicillium species; used in systemic treatment of superficial fungal infections.
a fungistatic antibiotic produced by Penicillium griseofulvum used orally for treatment of fungal infections of the skin. Toxic effects include bone marrow suppression and teratogenicity.