grepafloxacin


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grepafloxacin

Raxar® A broad-spectrum quinolone for acute bacterial exacerbation of chronic bronchitis caused by S pneumoniae, H influenzae, Moraxella catarrhalis; community-acquired pneumonia, Mycoplasma pneumoniae; uncomplicated gonorrhea caused by N gonorrhoeae; nongonococcal cervicitis and urethritis due to Chlamydia trachomatis. See Fluoroquinolone.
References in periodicals archive ?
Comparative pharmacokinetics of ciprofloxacin, gatifloxacin, grepafloxacin, levofloxacin, trovafloxacin, and moxifloxacin after single oral administration in healthy volunteers.
Doern, "Comparative bactericidal activities of ciprofloxacin, clinafloxacin, grepafloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Streptococcus pneumoniae in a dynamic in vitro model," Antimicrobial Agents and Chemotherapy, vol.
Other fluoroquinolones such as gemifloxacin, sparfloxacin, grepafloxacin, trovafloxacin, and garenoxacin have been shown to be effective against M.
Comparative antimycobacterial activities of ofloxacin, ciprofloxacin and grepafloxacin. J Antimicrob Chemother 1999; 44: 647-52.
(14,15) A study by Yamaguchi et al16 demonstrated that both grepafloxacin and levofloxacin undergo intestinal secretion via P-glycoprotein, and it was evidenced by decreases in their bioavailability when co-administered with the P-glycoprotein inhibitor cyclosporine.
aureus F265 has also been reported to have increased resistance to nalidixic acid, ciprofloxacin, moxifloxacin, trovafloxacin, grepafloxacin, levofloxacin and ofloxacin, compared to S.
Sparfloxacin and grepafloxacin were the most potent inhibitors of the HERG channel, with 50% inhibitory concentration ([IC.sub.50]) values of 18 [micro]M and 50 [micro]M, respectively.
Serious adverse drug effects in patients led to the withdrawal or restriction of four quinolones in the past decade (temafloxacin, grepafloxacin, trovafloxacin, and sparfloxacin).
Some of the fluoroquinolones in the studies are no longer routinely used for safety reasons, such as trovafloxacin (Trovan), which is not used in community-acquired pneumonia, and grepafloxacin, which is off the market.
Newer fluoroquinolones with higher in vitro activity against the pneumococcus, including levofloxacin, grepafloxacin, gatifloxacin, and moxifloxacin, are available in the United States.
Concerns about potential QT interval prolongation have prompted Glaxo Wellcome to voluntarily withdraw its quinolone, grepafloxacin, from the market.
$79.80 (10 days) (Cipro) sparfloxacin 400 mg day 1 $73.48 (10 days) (Zagam) followed by 200 mg/day for 9 days grepafloxacin Not applicable Not applicable (Raxar) PENICILLIN amoxicillin 500 mg t.i.d.