grayanotoxin


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Related to grayanotoxin: Andromedotoxin

grayanotoxin

(grā-yan'ō-toks-in),
A toxin produced by rhododendrons.
Synonym(s): rhodotoxin

grayanotoxin

(grā′ăn′ə-tŏk′sĭn)
n.
A neurotoxin found in the nectar of certain rhododendrons and related plants, such as some laurels of the genus Kalmia, and in unpasteurized honey produced from such nectar, and causing temporary effects such as nausea, vomiting, dizziness, and irregular heartbeat if ingested.

grayanotoxin

(grā″ăn′ŭ-tŏk′sĭn) [Fr. NL grayana, species name + ″. ]
A diterpene cyclic hydrocarbon found in honey produced by bees that feed on rhododendrons. Consumption of tainted honey or rhododendrons results in nausea, vomiting, and numbness and tingling around the mouth and in the arms and legs. Weakness, loss of coordination, and heart rhythm disturbances rarely occur, and only after massive ingestion. The poisoning typically resolves on its own within 24 hr.

grayanotoxin

the toxic tetracyclic polyol in plants of the Ericaceae family including rhododendron, azalea. Called also andromedotoxin or acetylandromedol.
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References in periodicals archive ?
IntroductionThe mad honey intoxication appears to be a clinical manifestation of use of grayanotoxin (GTX) isolated from the honey made by bees from the Rhododendron plant flowers mainly Ericaceae and Sapindaceae families.
Grayanotoxin poisoning: 'mad honey disease' and beyond.
Many of the Ericaceae family members produce diterpenoid grayanotoxins.
Grayanotoxin is a neurotoxin that binds to the sodium channels in the cell membrane, maintaining them in an open state and prolonging depolarisation.
Is the site of action of grayanotoxin the sodium channel gating of squid axon?
Distinct site regulating grayanotoxin binding and unbinding to D4S6 of Nav1.
Distinct sites regulating grayanotoxin binding and unbinding to D4S6 of Na(v)1.
Add a little honey for sweetness, but beware the maddening aftermath -- if that honey is contaminated with compounds called grayanotoxins.