Lilja et al (16) conducted a randomized, 4-phase, crossover study to look at the effect of
grapefruit juice dose on kinetics of triazolam.
At the end of the study period, the mice that ate the high-fat diet and drank diluted
grapefruit juice not only gained less weight than their control counterparts, they also had a 13 to 17 percent decrease in blood glucose levels and a threefold decrease in insulin levels, which reveals greater sensitivity to insulin.
Always ask the pharmacist if there are foods - including grapefruit or
grapefruit juice - that should be avoided while taking the medication.
The active ingredients responsible for interactions of
grapefruit juice with medication are not clearly identified.
Instead, we wanted to see if
grapefruit juice could be used in a controlled fashion to increase the availability and efficacy of sirolimus.
Cohen and his coauthors conducted three trials with 138 cancer patients, who either received just sirolimus, sirolimus and ketoconazole - another drug that can also slow the body's breakdown of sirolimus - or sirolimus and
grapefruit juice.
Since
grapefruit juice is reported to inhibit P-gp function, this study investigated the effect of the juice on the transport of CoQ10 by Caco-2 cells (a cell line used to model the lining of the human intestine).
Grapefruit juice contains three main furanocomarins.
Falling global inventories of orange juice and Florida inventories of
grapefruit juice also will exert upward pressure on 2009-10 farm prices, according to Mark Brown, senior research economist at the Florida Department of Citrus.
A freshly squeezed pink
grapefruit juice added a jolt of colour to our table as my dining partner and I picked our dishes from the one-page menu.
Grapefruit juice can increase blood levels of certain drugs three to five times, said study director Ezra Cohen, cancer specialist at the UCMC.
But it didn't get full respect until the 1960s, when fresh-squeezed
grapefruit juice began to appear in restaurants.
