grape seed extract

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Related to grape seed extract: Grapefruit seed extract

grape seed extract

(grayp seed ex-trakt) ,

Vitis vinifera

(trade name),

Vitis coignetiae

(trade name),

Oligomeric Proanthocyanidins (OPCs)

(trade name)


Therapeutic: cardioprotective agents
Chronic venous insufficiency, edema, diabetic retinopathy, varicose veins, cancer prevention, atherosclerosis, cirrhosis, prevention of collagen breakdown, vision problems, constipation, antioxidant, wound healing.


Grape flavonoids have a wide range of effects including antioxidant, vasodilatory, antiplatelet, decreased superoxide production, free-radical removal and inhibition of collagenase.

Therapeutic effects

Reduced risk of coronary disease.
Decreased skin and vasculature breakdown.


Absorption: Unknown.
Distribution: Unknown.
Metabolism and Excretion: Unknown.
Half-life: Unknown.

Time/action profile



Contraindicated in: Hypersensitivity or allergy to grape seed extract; Patients with bleeding disorders or receiving anticoagulant therapy.
Use Cautiously in: Obstetric: Avoid use in pregnancy due to lack of safety data.

Adverse Reactions/Side Effects


  • hypertension

Central nervous system

  • dizziness
  • headache


  • dry skin

Ear, Eye, Nose, Throat

  • sore throat
  • cough


  • nausea
  • diarrhea


  • ↑ risk of bleeding


May ↑ anticoagulant effects of warfarin.May ↓ plasma levels of CYP1A2 substrates.May inhibit the growth of lactobacillus acidophilus.May ↑ BP in hypertensive patients also takingvitamin c.
Oral (Adults) 75–300 mg daily.


Tablets :

Nursing implications

Nursing assessment

  • Monitor BP periodically during therapy.
  • Lab Test Considerations: Monitor serum cholesterol levels periodically during therapy.

Potential Nursing Diagnoses

Activity intolerance (Indications)


  • Administer as directed. Doses may vary.

Patient/Family Teaching

  • Advise patient not to take grape seed extract with Vitamin C; may cause increase in BP.
  • Advise female patients to notify health care professional if pregnancy is planned or suspected.

Evaluation/Desired Outcomes

  • Decrease in cholesterol.
  • Decrease in BP.
Drug Guide, © 2015 Farlex and Partners

grape seed extract

Abbreviation: GSE
An extract of antioxidant oils isolated from the seeds of grapes (Vitis vinifera) and promoted by alternative and complementary medical practitioners as a potential treatment for coronary artery disease, cancer, and other illnesses produced or worsened by oxidative stresses on body tissues. The extract has been used as a traditional European remedy for diseases of the eyes and skin seems to reduce postoperative swelling faster than placebo. Scientific evidence for its clinical effectiveness is sparse.
See also: extract
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Fractionation of high molecular weight tannins in grape seed extract and identification of procyanidin B2-3,3'-di-O-gallate as a major active constituent causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells.
In comparative experiments, the phenolic fraction of sea buckthorn fruits (at the highest tested concentration, 50 [micro]g/mL) turned out to be more effective than 50 [micro]g/mL Aronia extract or 50 [micro]g/mL grape seed extract (Figures 5-7).
(2010) reported a depression in intestinal length in birds fed on diet containing grape seed extracts. They also reported increased spleen weight along with immune boosting action of these extracts as main cause of increased spleen weight.
Antiproliferative and Apoptotic Effects Triggered by Grape Seed Extract (GSE) versus Epigallocatechin and Procyanidins on Colon Cancer Cell Lines.
You would reportedly have to eat large amounts of grape seeds to get the same benefit of manufactured grape seed extract
Naked Juice Gold Machine Superfood Smoothie is a blend of gold kiwi, yellow passion fruit and banana boosted with 11 vitamins and minerals including green tea, vitamin E, and grape seed extract. In fact, this is the first smoothie to have gold kiwi as an ingredient.
Adding grape seed extract to one's diet may help lower blood pressure.
Also try grape seed extract and the Chinese herb hu zhang, which help reverse free radical damage.
All subjects received a 3 mm forearm biopsy and were randomized to receive either a nutrient/enzyme blend containing a combination of proteases, bromelain, vitamin C (from calcium ascorbate), calcium (from calcium ascorbate and calcium citrate), rutin, grape seed extract (pycnogenol[R]) for seven days or a placebo.
It contains 1 gram of soluble fiber per serving, beta-carotene and lycopene, vitamins E, C, B6, B12, folic acid, green tea and ActiVin grape seed extract.
Rachel Perry's Environmental Skin Protector, SPF 18 ($27, 4 oz.), is a light cream made from antioxidants such as noni juice, pine bark extract, grape seed extract, beta glucan (derived from yeast and oats) and natural vegetable oils.