grape seed extract

Also found in: Dictionary, Thesaurus, Legal, Financial, Encyclopedia, Wikipedia.
Related to grape seed extract: Grapefruit seed extract

grape seed extract

(grayp seed ex-trakt) ,

Vitis vinifera

(trade name),

Vitis coignetiae

(trade name),

Oligomeric Proanthocyanidins (OPCs)

(trade name)


Therapeutic: cardioprotective agents
Chronic venous insufficiency, edema, diabetic retinopathy, varicose veins, cancer prevention, atherosclerosis, cirrhosis, prevention of collagen breakdown, vision problems, constipation, antioxidant, wound healing.


Grape flavonoids have a wide range of effects including antioxidant, vasodilatory, antiplatelet, decreased superoxide production, free-radical removal and inhibition of collagenase.

Therapeutic effects

Reduced risk of coronary disease.
Decreased skin and vasculature breakdown.


Absorption: Unknown.
Distribution: Unknown.
Metabolism and Excretion: Unknown.
Half-life: Unknown.

Time/action profile



Contraindicated in: Hypersensitivity or allergy to grape seed extract; Patients with bleeding disorders or receiving anticoagulant therapy.
Use Cautiously in: Obstetric: Avoid use in pregnancy due to lack of safety data.

Adverse Reactions/Side Effects


  • hypertension

Central nervous system

  • dizziness
  • headache


  • dry skin

Ear, Eye, Nose, Throat

  • sore throat
  • cough


  • nausea
  • diarrhea


  • ↑ risk of bleeding


May ↑ anticoagulant effects of warfarin.May ↓ plasma levels of CYP1A2 substrates.May inhibit the growth of lactobacillus acidophilus.May ↑ BP in hypertensive patients also takingvitamin c.
Oral (Adults) 75–300 mg daily.


Tablets :

Nursing implications

Nursing assessment

  • Monitor BP periodically during therapy.
  • Lab Test Considerations: Monitor serum cholesterol levels periodically during therapy.

Potential Nursing Diagnoses

Activity intolerance (Indications)


  • Administer as directed. Doses may vary.

Patient/Family Teaching

  • Advise patient not to take grape seed extract with Vitamin C; may cause increase in BP.
  • Advise female patients to notify health care professional if pregnancy is planned or suspected.

Evaluation/Desired Outcomes

  • Decrease in cholesterol.
  • Decrease in BP.

grape seed extract

Abbreviation: GSE
An extract of antioxidant oils isolated from the seeds of grapes (Vitis vinifera) and promoted by alternative and complementary medical practitioners as a potential treatment for coronary artery disease, cancer, and other illnesses produced or worsened by oxidative stresses on body tissues. The extract has been used as a traditional European remedy for diseases of the eyes and skin seems to reduce postoperative swelling faster than placebo. Scientific evidence for its clinical effectiveness is sparse.
See also: extract
References in periodicals archive ?
melanocarpa extract (50 [micro]g/mL, 15 min), and grape seed extract (50 [micro]g/mL, 15 min) on plasma lipid peroxidation induced by [H.
There is some published data available regarding use of grape by-products such as grape seed extracts or grape pomace in poultry (Brenes et al.
It has been found that grape seed extracts are rich in proanthocyanidin, a flavonoid related to sub-group of tannins, which protects blood vessels and helps cardiovascular system.
Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells.
Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells, Nutr.
It appears that an electrostatic spray of tartaric and malic acids and grape seed extract can be efficiently used to inhibit E.
More than 90 research presentations, publications and abstracts have been reported the health benefits regarding grape seed extract focusing on areas related to antioxidant activity, cardiovascular health, gastric health and anti-inflammatory properties.
In addition, studies involving grape seed extract (GSE) found that chronic exposure to GSE modulates expression of specific mouse brain proteins that are either linked to Alzheimer's Disease or neuron-degeneration (Deshane et al.
95) uses sweet almond oil, grape seed extract, lavender and vitamin E to calm and soothe dry patches on the face or body.
Naked Juice Gold Machine Superfood Smoothie is a blend of gold kiwi, yellow passion fruit and banana boosted with 11 vitamins and minerals including green tea, vitamin E, and grape seed extract.
Adding grape seed extract to one's diet may help lower blood pressure.
All subjects received a 3 mm forearm biopsy and were randomized to receive either a nutrient/enzyme blend containing a combination of proteases, bromelain, vitamin C (from calcium ascorbate), calcium (from calcium ascorbate and calcium citrate), rutin, grape seed extract (pycnogenol[R]) for seven days or a placebo.