granzymes

gran·zymes

(gran'zīmz),
Proteases with serine esterase activities that represent most of the granule content of T cytotoxic cells.
[granule + -zyme]
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Several studies have shown that Biobran increases NK cell granulated perforin and granzymes that, in turn, kill cancer cells by apoptosis.
The 5th international biobran workshop--new modern ways to treat cancer
In addition, [gamma][delta] T cells can secrete some cytotoxic components, such as perforin and granzymes, which eventually cause the direct or indirect effect of cytotoxicity [65].
The Role of [gamma][delta] Cells in Systemic Lupus Erythematosus
He demonstrated that the NK activity and the expression of granulysin, and granzymes A in the NK cells significantly increased after incubation.
How forests foster human health--present state of research-based knowledge (in the field of forests and human health)/Comment les forets contribuent a la sante des etres humains: etat actuel de la connaissance basee sur la recherche (dans le domaine des forets et de la sante humaine)/Como fomentan los bosques la salud humana-- estado actual del conocimiento basado en la investigacion (en el ambito de los bosques y la salud humana)
The cytotoxic effect of killers is realized in the target cell plasma membrane by special proteins--perforins, granzymes, etc.
Allotransplantation and its association with rising incidence of cancers
Release of granzymes and chemokines in Thai patients with leptospirosis.
Immune responses to Leptospira infection: roles as biomarkers for disease severity
Perforin is expressed in the granules of T-cells and NK-cells, and creates pores in the cytoplasm of targeted cells, thereby allowing granzymes and proteases to enter cells and ultimately induce apoptosis after entering the cell nucleus (1); however, the perforin gene mutation may not lead to the development of the clinical features of FHL until a patient .
Familial hemophagocytic lymphohistiocytosis with A665G perforin gene mutation: a case report / A665G Perforin Gen Mutasyonu Olan Ailesel Hemofagositik Lenfohistiyositozis: Bir Olgu Sunumu
OPs are particularly immunotoxic (Galloway and Handy 2003) and have been shown to suppress natural killer cells, lymphokine-activated killer cells, and cytotoxic T lymphocytes by inhibiting granzymes, impairing the FasL/Fas pathways, and inducing apoptosis of immune cells (Li 2007).
Tipping the balance of autism risk: potential mechanisms linking pesticides and autism
When the pro-apoptotic genes are activated, they secrete perforins and granzymes, cytotoxic mediators that form pores in the mitochondrial membrane of the cell injured, leaving it more susceptible to lysis (CHAIGNI-DELALANDE, et.
P53 gene: major mutations in neoplasias and anticancer gene therapy/Gene p53: principais mutacoes em neoplasias e terapia genica anticancer
Canonical pathways of cellular killing include: (i) exocytic granule mediated killing (these cytolytic granules contain preformed perforin, granzymes and likely also the microbicidal molecule granulysin), and (ii) activation of apoptosis/ programmed cell death pathways, e.
New insights and tools to combat leprosy nerve damage
With that pore in place, proteases known as granzymes can enter target cells and destroy them.
Study unearths well-kept secret of our immune system's success
proteins called perforin and granzymes A and B), and this inhibition leads to a decrease in the NK cells' ability to destroy their target cells.
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CD8+ cells secrete perforin and granzymes and also are capable of secreting cytokines such as IFN-GAMMA and TNFALPHA (Xing et al.
Morphological analyses of caseous necrosis Correlated to CD68+ AND CD8+ cells In biopsies of tuberculous pleurisy/Analisis morfologico de la necrosis caseosa y su correlacion con celulas CD68+ Y CD8+ en biopsias de pleuritis tuberculosa

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