granzymes

gran·zymes

(gran'zīmz),
Proteases with serine esterase activities that represent most of the granule content of T cytotoxic cells.
[granule + -zyme]
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The ELISpot and FluoroSpot Assay are using to detect various antibodies, cytokines, and granzymes. ELISpot and FluoroSpot Assay are a sensitive technique used for the recognition of immune cells which specific proteins such as cytokines or antibodies.
ELISpot and FluoroSpot Assay Market 2019 Global Industry Size, Share, Historical Analysis, Top Leaders, Business Growth, Regional Trends and Comprehensive Research Study Till 2023
Natural killer cells are also cytotoxic by releasing proteins called perforin that form holes in the cell membrane where granzymes enter to destroy the virus inside the cell.
New Understanding of Autoimmunity Development Through T Helper Cell Regulation, Part 2
Activated CAR T-cells release perforin and granzymes that attack tumour cells directly.
Chimeric Antigen Receptor (CAR) T-cell therapy; a promising outlook for refractory malignancies
Alefacept inhibits T effectors by apoptosis of T cells (releasing granzymes by the NK cells).
The role of regulatory T cells and anti-inflammatory cytokines in psoriasis
Tregs may also kill their target cells through cell contact-dependent cytolysis by granzymes A and B, in both perforin-dependent and perforin-independent manner, or induce apoptosis via the tumor necrosis factor-related apoptosis-inducing ligand-death receptor 5 (TRAILDR5) pathway, among other means [25].
Regulatory T Lymphocytes in Periodontitis: A Translational View
[CD8.sup.+] lymphocytes contribute to tissue injury and cell death in the lung via the release of proteolytic enzymes, such as perforin and granzymes [117-120].
Dysregulated Functions of Lung Macrophage Populations in COPD
The treatment also resulted in marked upregulation in the level of granzymes (granzymes B and C) and perforin protein concomitant to induce programmed cell death [12].
Cinnamon in Anticancer Armamentarium: A Molecular Approach
In the inflammatory sites, increased levels of neutrophil serine proteases (like elastase, cathepsin G, or chymotrypsin) [139], macrophagesderived PR3 and caspase-1 [140, 141], or granzymes from NK cells [142] are released from activated or dying cells and these enzymes cleave the N-terminal peptide of IL-1[beta] and release the active free C-terminal cytokine part (Figure 1).
Biologics for Targeting Inflammatory Cytokines, Clinical Uses, and Limitations
He demonstrated that the NK activity and the expression of granulysin, and granzymes A in the NK cells significantly increased after incubation.
How forests foster human health--present state of research-based knowledge (in the field of forests and human health)/Comment les forets contribuent a la sante des etres humains: etat actuel de la connaissance basee sur la recherche (dans le domaine des forets et de la sante humaine)/Como fomentan los bosques la salud humana-- estado actual del conocimiento basado en la investigacion (en el ambito de los bosques y la salud humana)
The cytotoxic effect of killers is realized in the target cell plasma membrane by special proteins--perforins, granzymes, etc., which lead to the formation in this organoid of perforations (pores).
Allotransplantation and its association with rising incidence of cancers
Release of granzymes and chemokines in Thai patients with leptospirosis.
Immune responses to Leptospira infection: roles as biomarkers for disease severity
The cytotoxic function of NK-cells and CTLs is mediated by release of cytolytic granules, which contain perforin, granzymes, and other serine-specific proteases, into the immunological synapse that forms between the effector and the target cell.
Familial hemophagocytic lymphohistiocytosis with A665G perforin gene mutation: a case report / A665G Perforin Gen Mutasyonu Olan Ailesel Hemofagositik Lenfohistiyositozis: Bir Olgu Sunumu

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