granulosa cell tumor


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.
Note: This page may contain terms or definitions that are offensive or inappropriate for some readers.

granulosa cell tumor

 [gran″u-lo´sah]
an ovarian tumor originating in the granulosa cells, the solid mass of cells surrounding the graafian follicle; it may be associated with excessive production of estrogen, inducing endometrial hyperplasia with menorrhagia.

gran·u·lo·sa cell tu·mor

a benign or malignant tumor of the ovary arising from the membrana granulosa of the vesicular ovarian (graafian) follicle and frequently secreting estrogen; it is soft, solid, white or yellow, and consists of small round cells sometimes enclosing Call-Exner bodies; larger lipid-containing cells may be present.
Synonym(s): folliculoma (1)

granulosa cell tumor

Gynecology A sex cord tumor of older ♀ that comprises 1-2% of ovarian neoplasms, which is 'driven' by unopposed estrogen stimulation; the endometrium of Pts with GCTs often has cystic hyperplasia and 5-25% of Pts also have a concomitant well-differentiated endometrial CA

gran·u·lo·sa cell tu·mor

(gran'yū-lō'să sel tū'mŏr)
A benign or malignant tumor of the ovary arising from the membrana granulosa of the ovarian (graafian) follicle and frequently secreting estrogen.
Synonym(s): folliculoma (1) .
References in periodicals archive ?
Prognostic significance of FOXL2 mutation and mRNA expression in adult and juvenile granulosa cell tumors of the ovary.
Granulosa cell tumors (GCTs) represent only 5% of all ovarian cancers.
Congenital testicular juvenile granulosa cell tumor in a neonatal with X/XY mosaicism.
Talerman, "Malignant granulosa cell tumor of the testis associated with gynecomastia and long survival," Cancer, vol.
Granulosa Cell Tumors. Granulosa cell tumors are sex cord tumors that make up 2-5% of ovarian neoplasms [77-80].
(7) Rare cases of neonatal abdominal juvenile granulosa cell tumors originating from from undescended testicles appear as well-circumscribed, multicystic and multiseptated masses.
[7] In the present study, among 7 sex cord stromal tumors encountered, 4 were diagnosed as adult granulosa cell tumors. All the cases presented with mass per abdomen, while one patient gave history of post-menopausal bleeding, these tumors were bilateral while one granulosa cell tumor was unilateral.
This is one of the best known ovarian tumors and has taken its place in their classification system for decades now but ironically, at least in my opinion, is a rare tumor that has received perhaps disproportionate interest in the literature in part because of its being 1 of the 2 often estrogenic neoplasms of the ovary, the other being the granulosa cell tumor. If one is stringent in diagnosing thecoma, it will be much less often encountered than the adult granulosa cell tumor.
Signet ring cell change in other ovarian sex cord-stromal neoplasms, such as fibroma, thecoma, or luteinized granulosa cell tumor, tends to develop from luteinized cells, and thus the cytoplasmic vacuoles contain lipid, which can be highlighted with histochemical stains.
One case of Granulosa cell tumor had endometrial hyperplasia due to estrogenic stimulus provided by the tumor.
Ovary.--In cases of LGEESS involving the ovary, the differential diagnosis is mainly with sex cord stromal tumors and includes adult granulosa cell tumor, fibroma, thecoma, and fibrosarcoma.
Calretinin and Inhibin were positive, EMA was negative in both adult and juvenile granulosa cell tumor. Immature teratoma showed S-100 protein positivity in neuroectodermal element.