granulosa cell tumor


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granulosa cell tumor

 [gran″u-lo´sah]
an ovarian tumor originating in the granulosa cells, the solid mass of cells surrounding the graafian follicle; it may be associated with excessive production of estrogen, inducing endometrial hyperplasia with menorrhagia.

gran·u·lo·sa cell tu·mor

a benign or malignant tumor of the ovary arising from the membrana granulosa of the vesicular ovarian (graafian) follicle and frequently secreting estrogen; it is soft, solid, white or yellow, and consists of small round cells sometimes enclosing Call-Exner bodies; larger lipid-containing cells may be present.
Synonym(s): folliculoma (1)

granulosa cell tumor

Gynecology A sex cord tumor of older ♀ that comprises 1-2% of ovarian neoplasms, which is 'driven' by unopposed estrogen stimulation; the endometrium of Pts with GCTs often has cystic hyperplasia and 5-25% of Pts also have a concomitant well-differentiated endometrial CA

gran·u·lo·sa cell tu·mor

(gran'yū-lō'să sel tū'mŏr)
A benign or malignant tumor of the ovary arising from the membrana granulosa of the ovarian (graafian) follicle and frequently secreting estrogen.
Synonym(s): folliculoma (1) .
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References in periodicals archive ?
Prognostic significance of FOXL2 mutation and mRNA expression in adult and juvenile granulosa cell tumors of the ovary.
A 20 YEARS' EXPERIENCE ON GRANULOSA CELL TUMOUR
Granulosa cell tumors (GCTs) represent only 5% of all ovarian cancers.
Granulosa Cell Tumor of the Ovary: A Retrospective Study of 31 Cases and a Review of the Literature
Congenital testicular juvenile granulosa cell tumor in a neonatal with X/XY mosaicism.
Juvenile Granulosa Cell Tumor of the Testis in a Newborn with Swelling in the Scrotum: A Rare Case and Literature Review
Talerman, "Malignant granulosa cell tumor of the testis associated with gynecomastia and long survival," Cancer, vol.
Metastatic Granulosa Cell Tumor of the Testis: Clinical Presentation and Management
Granulosa Cell Tumors. Granulosa cell tumors are sex cord tumors that make up 2-5% of ovarian neoplasms [77-80].
Anti-Mullerian hormone and its clinical use in pediatrics with special emphasis on disorders of sex development
(7) Rare cases of neonatal abdominal juvenile granulosa cell tumors originating from from undescended testicles appear as well-circumscribed, multicystic and multiseptated masses.
Neonatal juvenile granulosa cell tumor of the testis
[7] In the present study, among 7 sex cord stromal tumors encountered, 4 were diagnosed as adult granulosa cell tumors. All the cases presented with mass per abdomen, while one patient gave history of post-menopausal bleeding, these tumors were bilateral while one granulosa cell tumor was unilateral.
Non epithelial tumors of ovary
This is one of the best known ovarian tumors and has taken its place in their classification system for decades now but ironically, at least in my opinion, is a rare tumor that has received perhaps disproportionate interest in the literature in part because of its being 1 of the 2 often estrogenic neoplasms of the ovary, the other being the granulosa cell tumor. If one is stringent in diagnosing thecoma, it will be much less often encountered than the adult granulosa cell tumor.
Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD
Signet ring cell change in other ovarian sex cord-stromal neoplasms, such as fibroma, thecoma, or luteinized granulosa cell tumor, tends to develop from luteinized cells, and thus the cytoplasmic vacuoles contain lipid, which can be highlighted with histochemical stains.
Signet Ring Stromal Cell Tumor: A Legitimate (Benign) Mimic of Krukenberg Tumor
One case of Granulosa cell tumor had endometrial hyperplasia due to estrogenic stimulus provided by the tumor.
Postmenopausal bleeding: histopathological spectrum and association with age and clear span: case series of 328 cases
Ovary.--In cases of LGEESS involving the ovary, the differential diagnosis is mainly with sex cord stromal tumors and includes adult granulosa cell tumor, fibroma, thecoma, and fibrosarcoma.
Unusual Presentations of Gynecologic Tumors: Primary, Extrauterine, Low-Grade Endometrioid Stromal Sarcoma
Calretinin and Inhibin were positive, EMA was negative in both adult and juvenile granulosa cell tumor. Immature teratoma showed S-100 protein positivity in neuroectodermal element.
Role of immunohistochemistry in ovarian tumors

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