For a comprehensive evaluation, a bone marrow biopsy was also performed to evaluate the pancytopenia that showed cellular and left shift erythropoiesis, megaloblastoid changes, and left shift granulopoiesis
. The changes were suspicious but not specific to myelodysplastic syndrome, with other etiologies of consideration including medication nutritional supplements, immune disorders, heavy alcohol, vitamin B 12/folic acid deficiency, and viral infection.
Granulocyte colony-stimulating factor crosses the placenta and stimulates fetal rat granulopoiesis
. Blood 1993;81:916-22.
(11) The significant association of infused CD34+ dosage and platelet engraftment rather than neutrophil engraftment does support that the quality of stem cells function is better reflected by megakaryopoiesis rather than granulopoiesis
. (8) Granulopoiesis
seems not to be so much affected since all patients were given granulocyte colony-stimulating growth factor as it has been shown to enhance neutrophil engraftment.
Howell-Jolly body-like inclusions are thought to represent a product of dysplastic granulopoiesis
. In this light, we are curious to investigate the correlation of Howell-Jolly body-like inclusions and myelodysplastic syndrome (MDS).
IL-17 stimulates granulopoiesis
in mice: use of an alternate, novel gene therapy- derived method for in vivo evaluation of cytokines.
IL-17A is known as an inflammatory cytokine whose main function is exerted on myeloid and mesenchymal cells by inducing the expression of granulocyte colony-stimulating factor (G-CSF), IL-6, and other chemokines, which increase granulopoiesis
and recruit neutrophils into the site of infection .
Trimethoprim inhibits granulopoiesis
and erythropoiesis in vitro in a dose-dependent fashion .
IL-17A induces the production of defensins, cytokines, and chemokines and can promote granulopoiesis
and neutrophil recruitment .
showed that BM adipocytes block granulopoiesis
by cell-to-cell contact.
Saito et al., "Microbiota-derived compounds drive steady-state granulopoiesis
via MyD88/ TICAM signaling," The Journal of Immunology, vol.
Bone marrow biopsy demonstrated reduced cellularity (10-15%), reduced erythropoiesis, granulopoiesis
, and megakaryocytes.
Similarly, the continuous administration of CPH pectin showed no deleterious effects on neutrophils, suggesting that CPH pectin did not inhibit granulopoiesis
or neutrophil function.