granulomatous rosacea

gran·u·lom·a·tous ro·sa·ce·a

papular lesions in rosacea, characterized microscopically by perifollicular granulomas with central necrosis and scattered giant cells. Lupus miliaris disseminatus faciei is probably a form of granulomatous rosacea.
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On the other hand, granulomatous rosacea is defined as a variant, and it is characterized by sclerotic papules/nodules.
Isotretinoin is not typically used in rosacea, and it is most commonly used in the treatment of severe forms (granulomatous rosacea, rosacea conglobata or fulminans); it is administered in minidoses of 2.5 mg/day for about 6 months, but with close monitoring of its side effects (eye disturbances, angiogenesis stimulation, changes in serum transaminases).
Polymorphism R702W in NOD2/CARD15 is specifically associated with childhood granulomatous rosacea [35].
van Geel, "Granulomatous rosacea and Crohn's disease in a patient homozygous for the Crohn-associated NOD2/CARD15 polymorphism R702W," Experimental Dermatology, vol.
(8-10) Histologically, rosacea demonstrates intrafollicular and perifollicular lymphocytic inflammation with or without granulomas (granulomatous rosacea) or neutrophils (pustular rosacea).
Granulomas were detected in the 1 skin biopsy but it was interpreted as granulomatous rosacea.2.
* Granulomatous rosacea. This is a variant of rosacea characterized by uniform papules on the face.
Patients with granulomatous rosacea will need to be treated with the higher end of the tetracyclines--either minocycline or doxycycline (a known photosensitizer--and for a longer time period, she said.
Previously thought to be a tuberculid but now believed to be a variant of granulomatous rosacea.6 Actually, LMDF may be considered a distinct entity.5,6 The etiology remains unknown.1-3,6 Although, it is a self-limiting disease, the treatment options are tetracyclines, isotretinoin, dapsone and prednisolone.1-3 Clofazimine 100 mg three times weekly for 8 weeks has also shown successful results.1-3
Lymphocytoma cutis, granulomatous rosacea, leishmaniasis, leprosy, syphilis and follicular mucinosis were considered in the differential diagnosis.
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