granulomatous mastitis

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gran·u·lom·a·tous mas·ti·tis

a rare granulomatous inflammation of lobular breast tissue, with multinucleated giant cells; sarcoidosis is excluded by the frequent presence of neutrophils and absence of involvement of other tissues.

granulomatous mastitis

A rare inflammatory disease of the breast, often presenting as a tender mass. Symptoms usually appear within two years after a pregnancy. Even with mammography or ultrasonography, granulomatous mastitis may be difficult to distinguish from breast cancer without biopsy. Once the diagnosis is definitively established, the disease is treated with corticosteroids or by surgical removal of the mass.
See also: mastitis


inflammation of the mammary gland. Although it may be caused by chemical or physical agents, the causes are almost entirely infectious, and mostly bacterial. Clinical signs vary with the severity of the disease, but include pain, heat and swelling of the affected quarter or half or gland, and abnormality of the milk, either as clots or flakes, and wateriness of the liquid phase. Subclinical mastitis is the most important form and is diagnosed on the basis of bacteriological examination or by indirect tests, principally based on the cell count of the milk. Called also mammitis, garget. See also blue breast.
For a summary of the infectious agents which cause mastitis in each of the animal species consult Table 16. See also california mastitis test, wisconsin mastitis test.

acute mastitis
acute swelling of the mammary gland accompanied by heat and pain, together with grossly abnormal milk. There may be a slight systemic reaction.
black mastitis
severe, usually peracute clinical mastitis in which one or more quarters become gangrenous. Usually caused by Staphylococcus aureus.
botryomycotic mastitis
persistent local infection, usually by Staphylococcus aureus, causes granulomas and the collection of pus within them to produce a botryomycotic effect. See also coliform mastitis.
coliform mastitis
caused by Escherichia coli, Klebsiella spp. or Enterobacter aerogenes. See coliform mastitis.
contagious mastitis
caused by those bacteria which are resident in bovine udders or on teat skin and are spread primarily during milking. Staphylococcus aureus, Streptococcus agalactiae, S. dysgalactiae are the common causes. Called also 'cow-associated' mastitis.
mastitis control
aimed at reducing new infection rate and the static quarter infection rate; based on dry period treatment, culling or treating infected animals, teat disinfection, teat cup liner sanitization, and milking machine maintenance and correct use.
discarding mastitis milk
milk from infected quarters flushed to waste, not fed to calves.
mastitis dry cow treatment
intramammary infusion with a long-acting formulation, at the time of the last milking for the lactation; may be blanket (all cows) or selective (infected quarters only). See also dry period treatment.
environmental mastitis
caused by those bacteria which are usually resident in the environment of the cow, especially in the feces, bedding or water. Escherichia coli, Streptococcus uberis are the common infections. See also coliform mastitis.
gangrenous mastitis
the teat and much of the quarter are black and cold, the secretion is thin blood-stained fluid and there is a severe systemic reaction. The quarter is lost, and the cow may very well die.
granulomatous mastitis
see botryomycotic mastitis (above).
mastitis infection rate
rate of quarters or cows infected with pathogenic bacteria or showing clinical mastitis or, a much more commonly used index nowadays, the percentage of cows with a milk cell count in excess of a stated norm.
NIRD mastitis control program
the basis of all modern mastitis control programs. Named after the National Institute for Research in Dairying (now called the Animal Grassland Research Institute) at Reading, UK, which introduced dry period treatment and teat dipping into mastitis control. Highly effective in reducing the prevalence of contagious mastitis pathogens such as Streptococcus agalactiae, Staphylococcus aureus. Called also 'five point program'.
peracute mastitis
as for acute mastitis, but there is also a severe systemic reaction and the cow may die of the attending septicemia.
pyogranulomatous mastitis
a chronic disease in cattle caused by Nocardia asteroides, also occurs in sows caused by Actinomyces suis.
mastitis screening
testing for evidence of inflammation of mammary epithelium, of individual cows or entire herd, by use of milk cell counts, biochemical tests which measure products of inflammation, e.g. NAG-ase test, electrical conductivity.
subclinical mastitis
mastitis in which the only evidence of disease is an abnormality of cell count or other clinicopathological parameter.
summer mastitis
a serious disease likely to cause the loss of the quarter and a severe clinical illness. Caused by Arcanobacterium pyogenes and other unspecified cocci. See also Table 16.
suppurative mastitis
mastitis in which the secretion of the quarter is largely pus.
traumatic mastitis
mastitis in which the infection is introduced through the skin into the teat canal or mammary tissue by a penetrating injury; it is usually a mixed infection and causes a suppurative or gangrenous mastitis, depending on the bacteria that are present. The quarter is ruined and the cow may die. See also Table 16.
mastitis treatment withholding times
after intramammary infusion in lactating cow—withhold 72 hours; dry cow intramammary infusion—administered at least 4 weeks before calving, withhold for 96 hours after calving.
mastitis vaccination
not proven to exert beneficial effect. Only vaccination with an autogenous bacterin against Staphylococcus aureus, where the infecting organism is highly antigenic, appears to even reduce the severity of the disease.
References in periodicals archive ?
Conclusion: Patients with idiopathic granulomatous mastitis can present with a wide variety of symptoms which mimic other more common conditions.
In the current study, the sonographic findings of granulomatous mastitis tended to be large, irregular, and hypoechoic, with a diffuse tendency.
Fine needle aspiration cytology of granulomatous mastitis.
Rheumatologists and breasts: immunosuppressive therapy for granulomatous mastitis.
First report of idiopathic granulomatous mastitis treated with methotrexate monotherapy.
Idiopathic granulomatous mastitis (IGM) that mimics malignancy is a type of mastitis that has a chronic progression.
Idiopathic granulomatous mastitis is a rare neglected diagnosis which is important in differential diagnosis of breast cancer.
The recommended treatment of granulomatous mastitis is complete resection or corticosteroid therapy.
7%), which included 40 cases of abscess, 20 cases of granulomatous mastitis and 05 cases of chronic mastitis.
FNAC can be used for the diagnosis of inflammatory swellings of the breast such as breast abscess, granulomatous mastitis including tuberculosis where special stains like Zeil Nelson stain can be used to identify tubercle bacilli (11).
Granulomatous mastitis is a very rare breast inflammatory disease of unknown origin that can clinically and radiologically mimic carcinoma breast.
HPE showed features suggestive of granulomatous mastitis probably tubercular.

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