granulomatous disease

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chron·ic gran·u·lom·a·tous dis·ease

a congenital defect in the killing of phagocytosed bacteria by polymorphonuclear leukocytes, which cannot increase their oxygen metabolism due to dysfunctional NADPH oxidase, either because of defective cytochrome [MIM*233710 and MIM*233690] or other specific factor deficiencies [MIM*233700 and MIM*306400]. As a result there is an increased susceptibility to severe infection by catalase-positive microorganisms; inheritance is usually autosomal recessive or X-linked.

granulomatous disease

(1) A nonspecific term for any disease characterised by multiple granulomas.
(2) Chronic granulomatous disease, see there.

Granulomatous disease

Characterized by growth of tiny blood vessels and connective tissue.
References in periodicals archive ?
Basidiomycetous fungal Inonotus tropicalis sacral osteomyelitis in X-linked chronic granulomatous disease.
Patients who were treated by Ege University, Faculty of Medicine, Division of Pediatric Immunology for severe combined and combined immune deficiency (n=45), IL-12/IFN-Y receptor disorder (n=7), NEMO disorder (n=1), and chronic granulomatous disease (n=21) were evaluated retrospectively in terms of mycobacterial infections.
Idiopathic granulomatous mastitis is the most frequent form of all granulomatous diseases affecting the breast.
Tumor necrosis factor-alpha plays a role in the development of granulomatous diseases such as sarcoidosis.
Mycobacterial, fungal and other opportunistic infections force the clinician to rule out a large list of conditions associated with secondary immunodeficiency as infectious agents (HIV, Herpesvirus, HTLV), drugs (steroids, immunosuppressants, biologics, chemotherapy), metabolic diseases (diabetes, renal failure, cirrhosis), malignancies (leukemia, lymphomas and solid tumors) and environmental conditions (radiation, heavy metals) (2) but even adult patients can have late onset primary genetic immunodeficiency disorders as chronic granulomatous disease, X-linked agammaglobulinemia, interleukin-12 receptor deficiency or interferongamma (IFN-?
In such granulomatous disease, and in cases of persisting doubts, it is necessary to identify the specific etiological agent by further investigations such as special stains, culture methods and molecular techniques like polymerase chain reaction (PCR) and serological tests, as in the case of syphilis.
Granulomatous disease in common variable immunodeficiency.
Systemic sarcoidosis is an idiopathic, granulomatous disease that affects multiple organ systems but primarily the lungs and lymphatic system.
Geographic tongue and fissured tongue have been reported in association with chronic granulomatous disease .
Persistence of the bacterial pathogen Granulibacter bethesdensis in chronic granulomatous disease monocytes and macrophages lacking a functional NADPH oxidase.
Sarcoidosis, a chronic granulomatous disease of unknown etiology, acts in a manner similar to autoimmune diseases.
The NIH team is now working with collaborators on differentiation of the macaque iPSCs into liver, heart, and white blood cells for eventual clinical trials in hepatitis C, heart failure, and chronic granulomatous disease, respectively.

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