(b) Injured animals show DCX reactivity that demonstrates large clusters of immature cells, some inappropriately located in the middle and upper granule cell
(1) Immaturation of granule cells
in the DG was observed both in [alpha]-CaMKII hKO animals and in patients with schizophrenia [63, 74].
In line with these observations, perforant path stimulation and field potential recordings of granule cells
in vivo in urethane-anesthetized NL1 KO mice revealed strongly reduced synaptic responses upon the activation of glutamatergic perforant path granule cell
inputs (Figure 2).
Borhegyi et al., "Preservation of perisomatic inhibitory input of granule cells
in the epileptic human dentate gyrus," Neuroscience, vol.
This peak could be due to the mossy fiber-CA3 synapses originating from the younger granule cells
that, as reported in literature, display an increase of the input resistance giving a dramatic increase in granule cells
excitability ( see discussion).
For example, a time-lapse analysis of tangentially migrating granule cells
in the external granular layer of the cerebellum showed that a descending process into the molecular layer appears from the cell body that harbor a leading and a trailing process oriented horizontally, thus exhibiting a T-shape.
Quantitative results obtained by unbiased stereological techniques showed that exposure of rats to noise (100 dB, 30 min, 3 times per day) during one week from postnatal day 15 to 21 significantly decreases the volume of granular layer together with decreased numerical density of granule cells
in the cerebellum.
relay the information they receive from neurons involved in memory and cognition back to the olfactory bulb.
In the cerebellum, the loss of GABAergic inhibition may decrease tonic inhibition in cerebellar granule cells
(CGCs), leading to ataxia in Angelman syndrome .
Wang, "Morphological and biochemical changes during programmed cell death of rat cerebellar granule cells
," Neurochemical Research, vol.
death follows as a consequence of the loss of their primary neuron target population, the Purkinje cells: by the end of the second postnatal month, almost all Purkinje cells and 90% of the granule cells
have degenerated in the +/Lc cerebellum .
Nandy (1981) observed that the Purkinje cells are more prone to age changes than the granule cells
of the cerebellum regarding both lipofuscin formation and cell loss.