granins

granins

A family of acidic, soluble secretory proteins that include various chromogranins and secretogranins. The granins occur in vesicles in neurons and neuroendocrine cells. They are prohormones and give rise to bioactive peptides and can be used as markers of sympathoadrenal activity and of secretion from normal and neoplastic neuroendocrine cells into the bloodstream. Some granins are sensitive markers. Raised levels of chromogranin A, for instance, may allow confident diagnosis of PHAEOCHROMOCYTOMA, VON HIPPEL-LINDAU DISEASE or NEUROFIBROMATOSIS.
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Instead, BRCA1 is a secreted molecule belonging to an obscure family of proteins known as granins, the investigators said (SN: 3/2/96, p.
In addition, according to other researchers at a recent meeting on BRCA1, the Seattle-Nashville collaboration reiterated its belief that the gene's protein is a secreted granin.
Adding to that hope is a more controversial result from the same researchers: They contend that BRCA1, the protein encoded by BRCA1, is secreted by breast cells and belongs to an obscure family of proteins called granins.
In addition to secretion and the motif, granins share other characteristics with BRCA1, such as an unusual resistance to heat.
The granin model for BRCA1 appears to offer further evidence that the location of a mutation in the BRCA1 gene determines the risk of ovarian cancer, a hotly debated suggestion (SN: 12/21/95, p.
Chromogranins, including chromogranin A (CgA), are members of the granin family of neuroendocrine secretory proteins located in the secretory vesicles of neurons and endocrine cells.
We have previously demonstrated the potential of the granin proteins as prognostic biomarkers in patients with cardiovascular (CV) disease (3-6), including a recent study that identified SN as a potent prognostic biomarker in patients with acute heart failure (7).
The extended granin family: structure, function, and biomedical implications.
The human chromogranin A (CgA) protein, a member of the granin family, is an acidic 439 amino acid protein with a sequence containing several mono--and dibasic cleavage sites.
Human chromogranin A (CgA), a member of the granin family, is an acidic 439-amino acid protein with a widespread expression in endocrine cells and neurons (1-3).