gramicidin


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Related to gramicidin: framycetin

gramicidin

 [gram″ĭ-si´din]
an antibiotic produced by Bacillus brevis, applied topically in pyodermic, ocular, and other localized infections due to susceptible gram-positive organisms. It is also one of the two major components of tyrothricin, the other being tyrocidine.

gram·i·ci·din

(gram'i-sī'din),
One of a group of polypeptide antibiotics produced by Bacillus brevis that are primarily bacteriostatic in action against gram-positive cocci and bacilli. Commercial preparations contain several gramicidins known as gramicidin A, B, C, and D; gramicidin S (for Soviet) is cyclic, the others are linear.

gramicidin

(grăm′ĭ-sīd′n)
n.
An antibiotic produced by the soil bacterium Bacillus brevis and used to treat infections caused by certain gram-positive bacteria.

gram·i·ci·din

(gram'i-sī'din)
Polypeptide antibiotic that is bacteriostatic in action against gram-positive cocci and bacilli.

gramicidin

An antibiotic used externally in ointments and creams, often in conjunction with the antibiotics NEOMYCIN and FRAMYCETIN and with CORTICOSTEROIDS. It is too toxic for internal use. Brand names of various combinations with other drugs are Adcortyl, Graneodin, Neosporin, Sofradex, Soframycin and Tri-Adcortyl.

antibiotic 

1. Pertaining to the ability to destroy or inhibit other living organisms.
2. A substance derived from a mould or bacterium, or produced synthetically, that destroys (bactericidal) or inhibits the growth (bacteriostatic) of other microorganisms and is thus used to treat infections. Some substances have a narrow spectrum of activity whereas others act against a wide range of both gram-positive and gram-negative organisms (broad-spectrum antibiotics). Antibiotics can be classified into several groups according to their mode of action on or within bacteria: (1) Drugs inhibiting bacterial cell wall synthesis, such as bacitracin, vancomycin and the β-lactams based agents (e.g. penicillin, cephalosporins (e.g. ceftazidime, ceftriaxone, cefuroxime). (2) Drugs affecting the bacterial cytoplasmic membrane, such as polymyxin B sulfate and gramicidin. (3) Drugs inhibiting bacterial protein synthesis, such as aminoglycosides (e.g. amikacin sulfate, framycetin sulfate, gentamicin, neomycin sulfate and tobramycin), tetracyclines, macrolides (e.g. erythromycin and azithromycin) and chloramphenicol. (4) Drugs inhibiting the intermediate metabolism of bacteria, such as sulfonamides (e.g. sulfacetamide sodium) and trimethoprim. (5) Drugs inhibiting bacterial DNA synthesis, such as nalixidic acid and fluoroquinolones (e.g. ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin). (6) Other antibiotics such as fusidic acid, the diamidines, such as propamidine isethionate and dibrompropamidine. Syn. antibacterial. See antiinflammatory drug; fusidic acid.

gram·i·ci·din

(gram'i-sī'din)
One of a group of polypeptide antibiotics produced by Bacillus brevis that are primarily bacteriostatic in action against gram-positive cocci and bacilli.
References in periodicals archive ?
If the antibody finds the antigen it is seeking -- or the DNA probe detects a matching nucleotide sequence -- the binding reaction tugs at the synthetic gramicidin molecule, preventing contact between two segments of the molecule (one in the inner layer of the membrane, the other in the outer layer).
(14.) Berditsch M, Afonin S, Ulrich AS.The ability of Aneurinibacillus migulanus (Bacillus brevis) to produce the antibiotic gramicidin S is correlated with phenotype variation.
DNA-supercoiling is affected in vitro by the peptide antibiotics tyrocidine and gramicidin. Eur J Biochem [en linea].Noviembre 3 1986 [Revisado el 10 de Enero de 2011] 160(3):587-91; Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/2430800
(2003) conducted a multi-centered, randomized, double-blind, controlled trial in Canada comparing an antibiotic ointment composed of 500 units/g bacitracin, 0.25 mg/g gramicidin, and 10,000 units/g polymyxin B to placebo ointment applied at the HD catheter exit site.
They found secretion of antimicrobials; gramicidin, gatavalin, polymxin, subtilin, and tyrocidine by biofilms in continuous reactors.
Effects of gramicidin and tyrocidine on pathogenic protozoa and a spirochete.
Based on the clinical signs and findings of the physical examination, the owner elected for conservative, empirical therapy with triple-antibiotic ophthalmic solution (OS; 1 drop OS q8h; neomycin and polymyxin B sulfates and gramicidin ophthalmic solution).
(1) For 3 decades, the standard antibiotic treatment for CSOM in Aboriginal children had been a combination of topical 0.5% framycetin (neomycin B), gramicidin, and dexamethasone (FGD), a preparation that is potentially ototoxic.
The standard drops that have been used are made up of 0.5% neomycin B (framycetin), gramicidin, and dexamethasone.