graft-versus-host disease


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Related to graft-versus-host disease: cGVHD

graft-versus-host disease (reaction)

 (GVH disease)
a condition that occurs when immunologically competent cells or their precursors are transplanted into an immunocompromised recipient (host) that is not histocompatible with the donor. Because the host is immunocompromised, the graft is not rejected. Immunocompetent T lymphocytes derived from the donor tissue recognize the recipient's tissue as foreign or nonself and react with it, producing clinical manifestations including edema, erythema, ulceration, loss of hair, and heart and joint lesions similar to those of connective tissue disorders. This condition is a frequent complication of bone marrow transplantation. tissue typing and hla antigen matching of the donor and recipient reduce the possibility of graft-versus-host disease.

graft-versus-host disease

(grăft′vûr′səs-hōst′, -səz-)
n.
A condition in which cells from the transplanted tissue of a donor initiate an immunologic attack on the cells and tissue of the recipient.

graft-versus-host disease

Clinical immunology A reaction of donated BM against a Pt's own tissue, which is a major cause of M&M in allograft BMTs; GVHD is less significant in transplanted kidneys, heart, liver, and skin; viable donor T cells react immunologically against host Clinical Fever, morbiliform rash–central erythematous maculopapular eruption that may spread to the extremities with bulla formation, anorexia, N&V, severe watery or bloody diarrhea, lymphadenopathy, infections, hepatosplenomegaly, ↑ LFTs, jaundice, hemolytic anemia Prevention Irradiation of donated blood may prevent active leukocytes from rejecting recipient tissues Prophylaxis Cyclosporin, MTX, tacrolimus Treatment12 of Pts who develop post-BMT GVHD respond to high-dose steroids. See Bone marrow transplantation, Rapamycin, Tacrolimus, Transfusion-associated graft-versus-host disease.

graft-ver·sus-host dis·ease

(GVHD) (graft vĕr'sŭs hōst di-zēz')
An incompatibility reaction (which may be fatal) in a subject (host) of low immunologic competence (deficient lymphoid tissue) who has been the recipient of immunologically competent lymphoid tissue from a donor who lacks at least one antigen possessed by the recipient host; the reaction, or disease, is the result of action of the transplanted cells against those host tissues that possess the antigen not possessed by the donor.

graft-versus-host disease

A complication usually appearing two to three weeks after a bone marrow transplantation and caused by cytotoxic T cells in the donated marrow graft. These attack the host tissues causing liver inflammation (hepatitis) with obstruction to bile flow, diarrhoea and a severe scaling skin disease called exfoliative dermatitis. Drugs such as CYCLOSPORIN (ciclosporin) and high dose steroids must be used as the condition, once fully established, has a mortality of about 30%.

graft-ver·sus-host dis·ease

(GVHD) (graft vĕr'sŭs hōst di-zēz')
An incompatibility reaction (which may be fatal) in a subject (host) of low immunologic competence (deficient lymphoid tissue) who has been the recipient of immunologically competent lymphoid tissue from a donor who lacks at least one antigen possessed by the recipient host; the reaction, or disease, is the result of action of the transplanted cells against those host tissues that possess the antigen not possessed by the donor.
References in periodicals archive ?
Holler, "Graft-versus-host disease," The Lancet, vol.
Sun et al., "Allogeneic splenocyte transfer and lipopolysaccharide inhalations induce differential T cell expansion and lung injury: a novel model of pulmonary graft-versus-host disease," PloS One, vol.
Target: Rights to develop and commercialise ruxolitinib (Jakafi), its proprietary JAK1/JAK2 inhibitor, for graft-versus-host disease
Randomized clinical trial of thalidomide, cyclosporine, and prednisone versus cyclosporine and prednisone as initial therapy for chronic graft-versus-host disease. Biology of Blood and Marrow Transplantation, 7(5), 265-273.
Oral graft-versus-host disease. Dent Clin North Am 52: 79-109, viii-ix.
Clinicians feared this was a worsening of his graft-versus-host disease, but a GI work-up that included an intestinal biopsy showed no findings consistent with that diagnosis.
Five days after cessation of the iHg injections, both case and control mice were intravenously administered spleen cells from another mouse strain to induce chronic graft-versus-host disease (GVHD), a well-established murine model of acquired autoimmunity.
While this type of transplant often has an anti-leukemic effect, the risk is graft-versus-host disease (GVHD), in which the donated immune system (the graft) begins to attack the recipient's body (the host).
Graft-versus-host disease, the most severe complication from the combined regimen is "a double-edged sword since we're depending on the graft-versus-host reaction to provide the graft-versus-myeloma effect," Dr.