graft versus leukemia effect

graft versus leukemia effect

In allogeneic bone marrow transplantation, the killing of the recipient's leukemic clone by lymphocytes in the donated marrow.
Synonym: graft versus tumor effect
References in periodicals archive ?
This results in selectively depleting more GvHD-causing rivo-cel cells while sparing less alloreactive rivo-cel cells to continue to provide immunity and graft versus leukemia effect.
Allogeneic stem cell transplant (SCT) which depends on chemotherapy and immunotherapy (graft versus leukemia effect) is the only potential curative treatment for most patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and other myeloid malignancies.
This may be explained by inefficacy of immune surveillance function or graft versus leukemia effect outside the bone marrow cavity.