grade IV astrocytoma

grade IV as·tro·cy·to·ma

astrocytoma of high grade; World Health Organization designation.
See also: glioblastoma multiforme.

gli·o·blas·to·ma mul·ti·for·me

(glī'ō-blas-tō'mă mŭl'ti-fōr'mē)
A glioma consisting chiefly of undifferentiated anaplastic cells of glial origin that show marked nuclear pleomorphism, necrosis, and vascular endothelial proliferation; frequently, tumor cells are arranged radially about an irregular focus of necrosis; these neoplasms grow rapidly, invade extensively, and occur most frequently in the cerebrum of adults.
Synonym(s): grade IV astrocytoma.
[G. glia, glue, + blastos, germ, + -oma, tumor]
References in periodicals archive ?
Grade IV astrocytoma, GBM, is the most common type of glioma and has a survival time varying from less than 1 year to 3 years after initial diagnosis.
Chemotherapy is typically used for grade IV astrocytomas, with temozolomide being the currently preferred agent because it is administered orally, has a favorable side effect profile, and is generally well tolerated by patients (Claus & Black, 2006).
Grade IV astrocytoma is called glioblastoma, which has the highest degree of malignancy and also has an extremely poor prognosis.
740-kDa peak size <22, whereas 15% of grade II, 40% of grade III, and 48% of grade IV astrocytoma patients did (Fig.
10) Microvascular proliferation (MVP), loosely defined to include endothelial hypertrophy, endothelial hyperplasia, and glomeruloid vessels, and/or necrosis are distinguishing features of WHO grade IV astrocytoma, the latter being synonymous with the commonly used term glioblastoma multiforme or simply glioblastoma (GBM) in the current WHO scheme.