Anaplastic pleomorphic xanthoastrocytoma (APXA), an extremely rare primary brain tumour, is a WHO grade III astrocytoma
histologically defined by increased mitotic activity ([greater than or equal to] 5 mitoses /10 high-power field), with or without necrosis, and clinically notorious for its poor prognostic outcome compared to its benign variant the pleomorphic xanthoastrocytoma (PXA), a low-grade astrocytoma with more favourable prognosis first described by Kepes et al.
In the present study, the diagnosis was incorrectly made for five cases of gliomas, where two cases of Grade III Astrocytoma were wrongly diagnosed as cerebral abscess and Metastasis respectively, one case of Grade II astrocytoma was wrongly diagnosed as acute infarct, one case of Oligoastrocytoma was wrongly diagnosed as Meningioma, one case of GBM was wrongly diagnosed as Choroid plexus carcinoma.
Distribution of CNS Tumours According to Histopathology Tumour Number Grade II astrocytoma 6 Grade III astrocytoma 5 Glioblastoma multiforme 6 Oligodendroglioma/Subependymoma 1 Meningioma 18 Schwannoma 3 Pituitary macroadenoma 2 Craniopharyngioma 2 Medulloblastoma 1 Central neurocytoma 1 Tuberculoma 3 Secondaries 1 Oligoastrocytoma 1 Table 3.
It has been found that there is an association between PCNA-LI and histological grade implying that this marker could assist in discriminating between grade II and grade III astrocytoma
. (10) Studies showed that the highest PCNA and Ki-67 LI values were detected in glioblastoma (GBM) while pilocytic astrocytoma showed the lowest values.
But a biopsy revealed he has a grade III astrocytoma
after the eight-hour operation, chemotherapy and radiotherapy.
Western blot shows a 82 kDa TSGA10 band which was more intense in above-mentioned cell line (astrocyte derived from grade III astrocytoma
) than the astrocyte cell line (A735), as verified by scanning densitometry normalized to f3-actin (Figure 4).
P53 mutations are associated with 17p allelic: loss in grade II and grade III astrocytoma
. Grocer Res.
Two days after the scan, in August 2009, Ian underwent surgery where around 50% of the tumour was removed, but the biopsy revealed he has a grade III astrocytoma