In both macaque and rabbit models, sequential vaccination with gp120
and gp140 proteins has shown improved potency of neutralization, respectively [106, 107].
Mattson, "Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120
," JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.
To get around that, according to the university, the researchers found a piece of the gp120
protein that was common to many different HIV strains and used that to create their vaccine component, along with a sugar molecule that is likewise common to the strains.
A sugar shield covers the gp120
envelope, bolstering HIV's defenses.
The HIV-1 gp120
envelope protein consists of five hypervariable regions (V1-V5) interspersed among five constant regions (C1-C5), with the third variable loop (V3) region serving as the major determinant in HIV-1 coreceptor phenotype.
Ercal, "HIV proteins (gp120
and Tat) and methamphetamine in oxidative stress-induced damage in the brain: potential role of the thiol antioxidant N-acetylcysteine amide," Free Radical Biology & Medicine, vol.
Olson, and etal., "Vitronectin, fibronectin, and gp120
antibody enhance macrophage release of TNF-[alpha] in response to Pneumocystis carinii," Journal of Immunology, vol.
Human milk glycosaminoglycans inhibit HIV glycoprotein gp120
binding to its host cell CD4 receptor.
Disruption of the blood-brain barrier function as a fundamental mechanism facilitating the entrance of HIV in the CNS followed by a conjunction of direct and indirect viral factors, such as viral proteins gp120
, tat and vpR has been observed.
Several HIV-1 proteins have been shown to be involved in ROS production and responsible to enhance the oxidative stress during disease progression, these include Nef (9, 10), Tat (11), gp120
(12) and Vpr (13).
Phylogenetic analyses of the C2-V3 region of the HIV-1 gp120
gene, and related protease and reverse transcriptase genes demonstrated clustering of HIV viral strains among the outbreak cases and similarity between strains identified in the outbreak and other strains in Southeast Asia.