Last, we summarize understanding of the central role of the early induced innate immune response in
gouty inflammation, which has suggested the potential value of new strategies for treating
gouty inflammation by targeting caspase-1 or IL-1[beta].
They recommend that colchicine prophylaxis continue until the urate level has stabilized at the target level and the patient has not had an acute
gouty attack for 3-6 months.
Three-phase skeletal scintigraphy in
gouty arthritis: an example of potential diagnostic pitfalls in radiopharmaceutical imaging of the extremities for infection.
A diagnostic rule for acute
gouty arthritis in primary care without joint fluid analysis" (Arch.
These are individuals who, despite maximum therapy, continue to have high serum urate levels, tophi, or frequent
gouty attacks, some a combination.
Patients with a history of more than four
gouty attacks per year or with polyarticular attacks had higher serum urate during the episode studied than those without those characteristics.
While most humans have "normal" uric acid levels in the 4 to 7 mg/dL range, physicians know that many patients have serum uric acid levels that are higher, and it is these levels that tend to increase the risk for
gouty attacks, tophi, or both.
Allopurinol shouldn't be started during an acute
gouty attack and shouldn't be stopped in those already on treatment, he added.
In the NDA, Merck is seeking indications for ARCOXIA for the treatment of osteoarthritis, rheumatoid arthritis, chronic low back pain, acute pain, dysmenorrhea (menstrual pain), acute
gouty arthritis and ankylosing spondylitis.
Men with a history of
gouty arthritis have a significantly higher risk of acute myocardial infarction, reported Dr.
He was well known in London for sending his
gouty carriage-trade patients abroad to "take the waters" uncontaminated by lead.
Data from efficacy studies evaluating ARCOXIA versus naproxen in the treatment of ankylosing spondylitis and ARCOXIA versus indomethacin in the treatment of acute
gouty arthritis also are being presented at the annual meeting of the American College of Rheumatology.
