gossypol


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gos·sy·pol

(gos'i-pol),
A toxic principle isolated from the seed of the cotton plant (Gossypium) that reduces sperm count; used in China as an oral male contraceptive.
Farlex Partner Medical Dictionary © Farlex 2012

gossypol

An aromatic triterpene derived from cotton (Gossypum hirsutum) seed oil, which is 90% effective in reducing sperm counts to the level of infertility and thus flagged as a possible male contraceptive.
 
Cons
Nephrotoxicity, hypokalaemia; one-fourth become permanently sterile.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

gos·sy·pol

(gos'i-pol)
(Gossypium hirsutum) This plant's parts are thought to be of value as a male contraceptive (clinical studies done); other uses are as an antineoplastic and vaginal spermicide. Adverse effects reported include heart failure, hepatotoxicity, nephrotoxicity, and, with oral ingestion of seeds, death by poisoning.
Synonym(s): cotton.
[gossypium, + -ol]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Gossypol inhibits electron transport and stimulates ROS generation in yarrowia lipolytica mitochondria.
The starting material (-)-gossypol was first prepared according to a known procedure with modification [23], using L-trypto-phan methyl ester as an effective agent for the resolution of racemic gossypol. The yield of (--)-gossypol (2) obtained was comparable to that reported in the literature [23] (see Supplementary Material available online at https://doi.org/10.1155/2017/3687182).
Gossypol is a toxic polyphenolic compound present in cottonseed in two forms viz., free gossypol and bound gossypol.
Malvaceae: The first sesquiterpenoids discovered to be nematotoxic were the aldehydes hemigossypol and 6-methoxyhemigossypol, in addition the dimmers gossypol, and 6-methoxygossypol.
However, this plant contains a toxic compound, gossypol [1].
The most recent finding from the group is that the polyphenolic compound gossypol from the cotton plant and its derivative apogossypolone also cause oxidative damage to DNA by mobilizing endogenous copper in lymphocytes [180].
Vender Jagt, "Biologically active derivatives of gossypol: synthesis and antimalarial activities of peri-acylated gossylic nitriles," Journal of Medicinal Chemistry, vol.
In addition, NMR data indicated that peaks 1, 2, 4, 6, and 11 were gossypol (4.237 min), caffeoyl-D-glucose (12.770 min), 3-p-coumaroylquinic acid (17.895 min), gossypetin (19.704 min), and cichoric acid (34.083 min), respectively.
After its degumming and neutralization during the refining process, crude edible oil still contains undesirable impurities such as phospholipids, soap, trace metals, caratenoids, xanthophylls, chlorophyll, tocopherols and gossypol. These impurities not only impair the quality of the oil by altering its taste and color, but also affect its market value by giving it a color that will not be appreciated by the consumer.
The gossypol content of cottonseed meal was analyzed in the Aggeu Magalhaes Research Center (FIOCRUZ/PE) through the methodology described by the American Oil Chemical Society-AOCS (1997).
The limit in inclusion levels of CSC is determined by the level of gossypol [58, 59], a toxic phenolic compound that is found in the pigment glands of the cotton plant [60].