inhibits electron transport and stimulates ROS generation in yarrowia lipolytica mitochondria.
The starting material (-)-gossypol was first prepared according to a known procedure with modification , using L-trypto-phan methyl ester as an effective agent for the resolution of racemic gossypol
. The yield of (--)-gossypol (2) obtained was comparable to that reported in the literature  (see Supplementary Material available online at https://doi.org/10.1155/2017/3687182).
is a toxic polyphenolic compound present in cottonseed in two forms viz., free gossypol
and bound gossypol
Malvaceae: The first sesquiterpenoids discovered to be nematotoxic were the aldehydes hemigossypol and 6-methoxyhemigossypol, in addition the dimmers gossypol
, and 6-methoxygossypol.
However, this plant contains a toxic compound, gossypol
The most recent finding from the group is that the polyphenolic compound gossypol
from the cotton plant and its derivative apogossypolone also cause oxidative damage to DNA by mobilizing endogenous copper in lymphocytes .
Vender Jagt, "Biologically active derivatives of gossypol
: synthesis and antimalarial activities of peri-acylated gossylic nitriles," Journal of Medicinal Chemistry, vol.
In addition, NMR data indicated that peaks 1, 2, 4, 6, and 11 were gossypol
(4.237 min), caffeoyl-D-glucose (12.770 min), 3-p-coumaroylquinic acid (17.895 min), gossypetin (19.704 min), and cichoric acid (34.083 min), respectively.
After its degumming and neutralization during the refining process, crude edible oil still contains undesirable impurities such as phospholipids, soap, trace metals, caratenoids, xanthophylls, chlorophyll, tocopherols and gossypol
. These impurities not only impair the quality of the oil by altering its taste and color, but also affect its market value by giving it a color that will not be appreciated by the consumer.
content of cottonseed meal was analyzed in the Aggeu Magalhaes Research Center (FIOCRUZ/PE) through the methodology described by the American Oil Chemical Society-AOCS (1997).
The limit in inclusion levels of CSC is determined by the level of gossypol
[58, 59], a toxic phenolic compound that is found in the pigment glands of the cotton plant .