goserelin


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goserelin

 [go´sĕ-rel″in]
a synthetic gonadotropin-releasing hormone; upon administration it initially stimulates release of follicle-stimulating hormone and luteinizing hormone and on prolonged administration later suppresses them. It is used as the acetate salt to treat breast and prostate carcinomas and endometriosis and to thin the endometrium prior to endometrial ablation; administered by subcutaneous implant.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

gos·er·e·lin

(gos'ĕr-ĕ-lin),
A synthetic decapeptide agonist analogue of LHRH (GnRH). It inhibits pituitary gonadotropin secretion and is used to treat prostate cancer, breast cancer, endometriosis, and for prethinning the endometrium before endometrial ablation or resection.
Farlex Partner Medical Dictionary © Farlex 2012

goserelin

(gō′sə-rĕl′ĭn)
n.
A synthetic peptide analog of gonadotropin-releasing hormone used to treat prostate cancer, endometriosis, and advanced breast cancer.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

gos·er·e·lin

(gō'sĕr-el'in)
A synthetic decapeptide agonist analogue of the luteinizing hormone-releasing hormone (GnRH); it inhibits pituitary gonadotropin secretion and is used in the treatment of prostate cancer, breast cancer, endometriosis, and for thinning the endometrium before endometrial ablation or resection.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

goserelin

A gonadotrophin-releasing hormone used as a drug to treat ENDOMETRIOSIS, uterine FIBROIDS, MENORRHAGIA and cancer. A brand name is Zoladex.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Among the GnRH analogue class of medications, elagolix and goserelin are the least expensive.
European randomized multicenter study of goserelin (Zoladex) in the management of mastalgia.
Multicenter randomized clinical trial of goserelin versus surgical ovariectomy in premenopausal patients with receptor-positive metastatic breast cancer: an Intergroup Study.
Combined androgen blockade with goserelin and bicalutamide was started three years ago.
She was progressing on goserelin and capecitabine at the time of first blood sample in May 2013, which had amplified ERBB2, TP53 mutation (VAF = 6.5%), and a subclonal PIK3CA mutation (VAF = 2.5%) in cfDNA, suggesting resistant disease.
For example, NMBR genetargeted drugs included Bombesin and Ranatensin; GNRHR was the target of Degarelix, Nafarelin, Cetrorelix, Goserelin, and Leuprolide; F2RL3 gene was related to Argatroban.
No metastases were detected, and treatment with both the nonsteroidal antiandrogen bicalutamide (Casodex) and goserelin (Zoladex) reduced his PSA level to 0.2 ng/mL within three months.
Catamenial epilepsy and goserelin. Lancet 1991; 338: 1530-0.
The main exclusion criteria were as follows: (1) Pregnancy, (2) current or past history of malignancy, or current contraindication to either goserelin, Kuntai or Tibolone as documented in the summary of product characteristics for each product, (3) hormone therapy in the last 4 weeks before study entry, or usage of any drug, nutritional supplement, food or Traditional Chinese Medicine against climacteric complaints, (4) psychoactive drugs, (5) body mass index > 28 kg/m [sup]2 , (6) irregular gynecological bleeding in the last 4 weeks before medication start, cervical smear examination with any intraepithelial pathologic change (i.e.
The drug, goserelin, suppresses the ovaries from premature ovarian failure during cancer treatment and seen preserve future fertility.
They all had standard chemo, and half also had monthly shots of goserelin, a drug to lower estrogen and temporarily put the ovaries at rest.
They examined a wide spectrum of testosterone levels, and the adverse effects of different levels, by temporarily suppressing the normal endogenous gonadal steroids of healthy men aged 20-50 years using subcutaneous goserelin. In one cohort, 198 men then were randomly assigned to receive placebo or 1.25 g, 2.5 g, 5 g, or 10 g of a topical testosterone gel daily for 16 weeks.