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pri·mor·di·al germ cell

the earliest undifferentiated sex cell, found initially outside the gonad.
Synonym(s): gonocyte
Farlex Partner Medical Dictionary © Farlex 2012


The primordial germ cell central to gametogenesis (spermatogenesis in males; oogenesis in females).

Gametogonia (spermatogonia and oogonia), oocytes, ootids, ova.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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The researchers assessed the effect of treatments by counting gonocytes within the tissue samples.
The present results indicated that exposure of mice to 3 [micro]T of 50 Hz magnetic field from 0 day of gestation affects testicular development by reducing the population of Sertoli cells, destroying gonocytes, and rupturing tubules or cords in a way that Sertoli-like cells infiltrated into the interstitial tissue.
Effect of exposure to vehicle or DBP (500 mg/kg/day) on the induction of multinucleated gonocytes (MNGs) in rat testes at E21.5 (A-C) and in human fetal testis xenografts (D-F).
In treated male fetuses (n = 11), testis weight was significantly reduced (32%), as were the numbers of Sertoli cells (34% reduction), Leydig cells (37% reduction), and gonocytes (44% reduction), compared with control fetuses (n = 8).
(38,39) Normal Sertoli cell function is important for the maturation of gonocytes in the early testis, and delayed maturation, as already discussed, predisposes to germ cell neoplasia but at an unknown frequency.
Avarbock et al., "Prepubertal human spermatogonia and mouse gonocytes share conserved gene expression of germline stem cell regulatory molecules," Proceedings of the National Academy of Sciences of the United States of America, vol.
According to recent knowledge testicular physiology is marked by the transformation of neonatal gonocytes in the period from 3 to 12 months after birth.
First at 2-3 months there is surge in gonadotrophin and testertosterone (Mini puberty) that triggers the transformation of the fetal stem cell pool (Gonocytes) in to the adult sperm cell pool (Adult dark spermatogonia).
During normal development, neonatal gonocytes transform into adult dark spermatogonium at approximately six months of age (Hutson et al., 2013).
Approximately 95% of primary testicular tumors arise from embryonic germ cells, either primordial germ cells (PGCs) or gonocytes, and, as such, are more appropriately referred to as testicular GCTs.