In principle, laboratory methods for susceptibility testing of gonococci
are similar to those for other bacteria.
By 1944, however, many gonococci
had become resistant to sulphanilamide and treatment failure was observed in over 30% of patients.
Moreover, our method could be a valuable molecular tool in an effective antimicrobial strategy to control gonococci
This limitation is particularly relevant for the PorB-PCR PIA target, which as previously described, does not specifically target a mechanism of resistance, yet is highly associated with penicillin susceptibility in local Australia gonococci
Given the speed with which gonococci
developed resistance to fluoroquinolones, the CDC sees as inevitable the eventual development of resistance to cephalosporins--the currently favored agents for gonorrhea.
For further examination of cross-immunity of MenB vaccines with gonococci
, vaccine effectiveness studies in regions where OMV vaccine was used (e.
Gonorrhoea is one of the most common sexually transmitted disease caused by Neisseria gonococci
The continued increase in antibioticresistant gonococci
is the driving force behind 3 new gonorrhea treatment recommendations: (1) injectible ceftriaxone should be used rather than oral cefixime; (2) the ceftriaxone dose should be doubled from 125 to 250 mg; and (3) 1 g oral azithromycin should be administered (in addition to ceftriaxone), whether or not a chlamydial infection has been ruled out.
For example, rapid results of throat cultures for group A streptococci or of genital cultures for gonococci
and Chlamydia trachomatis in outpatients can guide an early therapeutic decision.
These efforts should be used in public health responses to mitigate emergence and spread of ESC-resistant gonococci