Conditional knockout of the androgen receptor in gonadotropes
reveals crucial roles for androgen in gonadotropin synthesis and surge in female mice.
By the localization of anti-tGH, anti-chPRL positive cells, previously reported (Sonez et al., 1995), the caudal and cephalic lobes can be distinguished respectively, and also LH and FSH gonadotropes
Thieulant ML (1990) Combretodendron africanum bark extract as an antifertility agent: I: estrogenic effects in vivo and LH release by cultured gonadotrope
Signaling responses to pulsatile gonadotropin-releasing hormone in LbetaT2 gonadotrope
Liver receptor homologue-1 regulates gonadotrope
Roberson, "GnRH signaling, the gonadotrope
and endocrine control of fertility," Frontiers in Neuroendocrinology, vol.
Webster, "Gonadotropin-releasing hormone induces miR-132 and miR-212 to regulate cellular morphology and migration in immortalized L2 T2 pituitary gonadotrope
cells," Molecular Endocrinology, vol.
This peptide reaches the anterior pituitary gland via hypothalamic 'pituitary portal system to stimulate release of mainly LH and to a lesser extent, FSH from specialized cells referred to as gonadotropes
or beta cells.
Halvorson, "GnRH decreases adiponectin expression in pituitary gonadotropes
via the calcium and PKA pathways," Reproductive Sciences, vol.
Each action potential translates into a pulsatile secretion of Kisspeptin on to the axons of the GnRH neurons in the median eminence, thence GnRH is released towards the pituitary gonadotropes
, via the portal circulation.
Kottler, "The expression of aromatase in gonadotropes
is regulated by estradiol and gonadotropin-releasing hormone in a manner that differs from the regulation of luteinizing hormone," Endocrinology, vol.
We will adopt a transgenic approach combined with state-of-the-art live imaging techniques to investigate the intricate interplay between GnRH and gonadotropes
in the teleost pituitary.