From the outpatient clinic file records of patients, their weight, height, puberty phase according to Marshall and Tanner (19), basal serum LH, follicle stimulating hormone (FSH), and estradiol studied from venous blood samples taken between 08.00-12.00 after 12-hour fasting, peak serum LH level after exogenous GnRH (gonadorelin
100 [micro]g) intravenous injection, bone age assessment according to the Greulich and Pyle (20) method, and cranial imaging results were recorded.
In this study, we investigated the cut-off values of the GnRH (gonadorelin
) stimulation test to discriminate between IHH and CDP by estimating the values of LH and FSH at various time points after GnRH stimulation, and evaluating the sensitivity and specificity of the test.
LH and FSH response of Holstein heifers to fertirelin acetate, gonadorelin
On day 9 (72h after the treatment with eCG), 100[micro]g of gonadorelin
im (GnRH, Profertil[R], Tortuga, Brazil) was administered to all of the animals (Figure 1).
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We termed this concept the neuro-osseous timing of maturation (NOTOM) hypothesis, and used it to propose a possible medical treatment for idiopathic scoliosis by delaying puberty through the pituitary using gonadorelin
analogues as in idiopathic precocious puberty.
Degradation kinetics of three gonadorelin
analogues: developing a method for calculating epimerization parameters.
The measurement of hormone reserve and regulation by dynamic tests [L-arginine test (300 mL 10% L-arginine IV within 30 min: normal increase of growth hormone), thyrotropin-releasing hormone test, gonadotropin-releasing hormone test (Gonadorelin
; Relefact LH-RH 0.100 mg; 1 mL as bolus IV; normal increase of follicle-stimulating hormone and luteinizing hormone), adrenocorticotropic hormone (ACTH) test (121 pg corticorelin-trifluoroacetate IV; normal increase of cortisol, testosterone, dehydroepiandrosterone-S, 17 [alpha]-hydroxyprogesterone, and androstendion) (11)] revealed normal results, which ruled out the possibility of a disturbance of the hypothalamic-pituitary--target system.
This test involves intravenous infusion of 30 U of GnRH gonadorelin
and measurement of gonadotropins at 0, 20, 40, and 60 minutes after infusion.