gold compound


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Any second-line gold-based anti-rheumatic—e.g., aurothioglucose, gold sodium thiomalate, auranofin—used to treat rheumatoid arthritis and other arthropathies, which protects membrane proteins and lipids from oxidative degradation and quench singlet O2 generated as free radicals
Adverse effects GI tract (e.g., diarrhoea, abdominal pain, nausea, vomiting—partially relieved by cromolyn sodium), renal (e.g., nephrotic syndrome, proteinuria, rash, blood dyscrasias, hepatitis)

gold compound

Rheumatology Any 2nd-line gold-based anti-rheumatic–eg, aurothioglucose, gold sodium thiomalate, auranofin to treat rheumatoid arthritis and other arthropathies Side effects GI tract–eg diarrhea, abdominal pain, N&V, partially relieved by cromolyn sodium, renal–eg, nephrotic syndrome, proteinuria, rash, blood dyscrasias, hepatitis. See Gold lung.
References in periodicals archive ?
1) Gold compounds that could not be transformed into colloidal gold in vivo were ineffective as anti-tumor agents.
In subsequent experiments in cell culture, gold compounds were shown to render the immune system antigen presenting cells inactive, further strengthening this connection.
Synthetic DMARDs include azathioprine (Imuran), cyclosporine (Sandimmune, Neoral), gold compounds, hydroxychloroquine (Plaquenil), leflunomide (Arava), methotrexate, penicillamine, and sulfasalazine (Azulfidine).
Splash Lube Gold Compounds, a low-cost bearing material for lubricated environments introduced by RTP Co., are said to offer maximum tribological properties at a lower cost than other thermoplastic systems.