gold compound


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gold compound

a drug containing gold salts, usually administered with other drugs in the treatment of rheumatoid arthritis. Gold is potentially toxic and is administered only under the supervision of a specialist in chrysotherapy. Toxic reactions range from mild dermatoses to lethal poisoning. Various radioisotopes of gold have been used in diagnostic radiology and in radiological treatment of certain malignant neoplastic diseases.
Any second-line gold-based anti-rheumatic—e.g., aurothioglucose, gold sodium thiomalate, auranofin—used to treat rheumatoid arthritis and other arthropathies, which protects membrane proteins and lipids from oxidative degradation and quench singlet O2 generated as free radicals
Adverse effects GI tract (e.g., diarrhoea, abdominal pain, nausea, vomiting—partially relieved by cromolyn sodium), renal (e.g., nephrotic syndrome, proteinuria, rash, blood dyscrasias, hepatitis)

gold compound

Rheumatology Any 2nd-line gold-based anti-rheumatic–eg, aurothioglucose, gold sodium thiomalate, auranofin to treat rheumatoid arthritis and other arthropathies Side effects GI tract–eg diarrhea, abdominal pain, N&V, partially relieved by cromolyn sodium, renal–eg, nephrotic syndrome, proteinuria, rash, blood dyscrasias, hepatitis. See Gold lung.
References in periodicals archive ?
Another consequence: the gold compounds that are difficult to absorb transform in the outer area of the cell into harmless gold nuggets only a few nanometres in size," Nies said in (http://pressemitteilungen.
In subsequent experiments in cell culture, gold compounds were shown to render the immune system antigen presenting cells inactive, further strengthening this connection.
Synthetic DMARDs include azathioprine (Imuran), cyclosporine (Sandimmune, Neoral), gold compounds, hydroxychloroquine (Plaquenil), leflunomide (Arava), methotrexate, penicillamine, and sulfasalazine (Azulfidine).