This suggests that there might be other
goitrogens or factors playing a role besides iodine deficiency that need to be explored.
Antithyroid sulfurated compounds in environmental
goitrogens, Gaitan E, editors.
Iodine metabolism in response to
goitrogen induced altered thyroid status under conditions of moderate and high intake of iodine.
Bromate is a
goitrogen, carcinogen, and a zombifying agent.
Variable effects of
goitrogens in inducing precocious metamorphosis in sea lampreys (Petromyzon marinus).
A questionnaire relating thyroid disorders and
goitrogens was given to them and analysis was done.
1,2) The greater demand for iodine may be due to the
goitrogen load in these subjects.
An additional group was administered the
goitrogen PTU (6-n-propyl-2-thiouracil; Sigma-Aldrich Chemicals GmbH, Steinheim, Germany), which served as a reference control for TH effects.
With daily intake ranging from 6 mg to 180 mg iodine, a success rate as high as 90% was achieved, (3) saving patients' thyroids from radioiodide and the toxic
goitrogens.
Despite the finding that PCBs uniformly reduce circulating levels of TH in experimental animals, PCBs do not exert effects in experimental animals that are fully consistent with experimentally produced hypothyroidism using
goitrogens such as propylthiouracil (PTU).
1) Patients who used water from wells and municipal plants may be exposed to potassium perchlorate, a very powerful
goitrogen that behaves like fluoride, binding to the halide-binding site of the symporter without itself being symported.
31) Bromide is a
goitrogen and interferes with iodide utilization by the thyroid gland, (32-34) and possibly by the mammary gland also.
