goblet cell carcinoid

goblet cell carcinoid (appendix)

A type of mixed endocrine/exocrine neoplasm with both endocrine and glandular differentiation.

Clinical findings
GCCs are more aggressive than classic carcinoid tumours, and behave as low-grade malignancies.
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References in periodicals archive ?
Goblet cell carcinoid tumors may also contain signet ring-like cells, but these contain PAS-positive material and will express neuroendocrine and epithelial markers.
Since carcinoid tumor was first described by Merling (2) in 1838, three different histological subtypes have been described: argentaffin-positive carcinoid; non-argentaffin carcinoid; and goblet cell carcinoid (GCC) (3).
Incidentally, the final pathology showed a small invasive appendiceal adenocarcinoma arising in the background of goblet cell carcinoid with negative lymph nodes and negative margins staged as T3N0.
Torii, "A case of goblet cell carcinoid of appendix with repeated appendicitis," Journal of Japan Society for Endoscopic Surgery, vol.
Goblet cell carcinoid is a rare tumor and was first described by Gagne in 1969.
Table 1: WHO Classification of Tumours of the Appendix Epithelial Tumours Adenoma Carcinoma Adenocarcinoma Mucinous adenocarcinoma Signet-ring cell carcinoma Small cell carcinoma Undifferentiated carcinoma Carcinoid Tubular carcinoid Goblet cell carcinoid (Mucinous carcinoid) Mixed carcinoid-adenocarcinoma Others Non-Epithelial Tumours Neuroma, Lipoma, Leiomyoma Gastrointestinal stromal tumour Leiomyosarcoma, Kaposi sarcoma Malignant Lymphoma Secondary tumours and Hyperplastic (Metaplastic) polyp Courtesy-WHO Classification of Tumours (Ref 9)
Goblet cell carcinoid was diagnosed in 2 cases with predominating neoplastic infiltration of submucosa in one of them and with more extensive infiltration of tunica muscularis in the second tumour.
Histopathology of the Vermiform appendix confrimed it was a goblet cell carcinoid.
The presence of mucin in the neuroendocrine component is reminiscent of goblet cell carcinoid. Goblet cell carcinoid is a special type of neuroendocrine tumor that usually occurs in the appendix, but may occasionally be present in other gastrointestinal organs (6).
A few days later, histopathology of the specimen revealed a 2.2 cm goblet cell carcinoid tumor located in the appendix tip.
In addition, clusters of cells simulating GCT but with increased cytologic or architectural atypia beyond typical goblet cell carcinoid nests (enlarged or irregular nests/glands, increased cytologic atypia, increased mitotic activity) were also considered areas of adenocarcinoma.
Appendiceal goblet cell carcinoid. A, Hematoxylin-eosin.