goblet cell carcinoid

goblet cell carcinoid (appendix)

A type of mixed endocrine/exocrine neoplasm with both endocrine and glandular differentiation.

Clinical findings
GCCs are more aggressive than classic carcinoid tumours, and behave as low-grade malignancies.
References in periodicals archive ?
Table 1: WHO Classification of Tumours of the Appendix Epithelial Tumours Adenoma Carcinoma Adenocarcinoma Mucinous adenocarcinoma Signet-ring cell carcinoma Small cell carcinoma Undifferentiated carcinoma Carcinoid Tubular carcinoid Goblet cell carcinoid (Mucinous carcinoid) Mixed carcinoid-adenocarcinoma Others Non-Epithelial Tumours Neuroma, Lipoma, Leiomyoma Gastrointestinal stromal tumour Leiomyosarcoma, Kaposi sarcoma Malignant Lymphoma Secondary tumours and Hyperplastic (Metaplastic) polyp
Goblet cell carcinoid of the appendix: a specific type of carcinoma.
Histopathology of the Vermiform appendix confrimed it was a goblet cell carcinoid.
Goblet cell carcinoid tumor (GCT)--also termed mucinous carcinoid tumor, (2) mixed crypt cell carcinoma, (3,4) adenocarcinoid-goblet cell type, (5,6) and microglandular goblet cell carcinoma (7)--is a unique neoplasm occurring almost exclusively in the appendix.
9,10) In contrast, goblet cell carcinoid tumors of the appendix are rare, and they have a mixed phenotype with partial neuroendocrine differentiation and intestinaltype goblet cell morphology.
Dr Laura Tang addresses tumors of the appendix, focusing on mucinous neoplasms and the spectrum of neuroendocrine tumors, including goblet cell carcinoid tumor.
17-19) A mucin stain may be used, in some cases, for the differential diagnosis with a goblet cell carcinoid (see below).
Appendiceal goblet cell carcinoid (GCC) is rare, with a significantly higher metastatic rate than the conventional appendiceal carcinoid.
Goblet cell carcinoid is a neuroendocrine malignancy with a unique appearance, characterized by the presence of both nests and glands lined by endocrine cells and by goblet cells.
Goblet cell carcinoid of the appendix as a distinct entity was first described in 1974.
According to Stancu and colleagues, goblet cell carcinoids did not show mutations in SMAD4 (18).
Most typically found in the appendix, goblet cell carcinoids (GCCs) can also be found in other areas of the GI tract.