gnotobiotic


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gno·to·bi·ot·ic

(nō'tō-bī-ot'ik),
Denoting germ-free or formerly germ-free organisms in which the composition of any associated microbial flora, if present, is fully defined.
[see gnotobiota]

gnotobiotic

Biology
adjective Referring to a system to which only preselected components, organisms and nutrients are introduced. Gnotobiotic organisms are either experimental models (e.g., mice with naïve immune systems), or “experiments of nature”, in which the natural immune defence is grossly defective (e.g., severe combined immune deficiency); prolonged survival of the host requires complete avoidance of exposure to pathogens.

gno·to·bi·ot·ic

(nō'tō-bī-ot'ik)
Denoting germ-free or formerly germ-free organisms in which the composition of any associated microbial flora, if present, is fully defined.

gnotobiotic

literally ‘known life’; typically referring to an environment or animal that is essentially germ-(microorganism-) free, or one in which the microbial flora present is known, usually because it has been deliberately introduced.
References in periodicals archive ?
Blanton et al., "Regulators of gut motility revealed by a gnotobiotic model of diet-microbiome interactions related to travel," Cell, vol.
Saif, "Immune responses to bovine norovirus-like particles with various adjuvants and analysis of protection in gnotobiotic calves," Vaccine, vol.
Gnotobiotic piglet infection model for evaluating the safe use of antibiotics against Escherichia coli O157:H7 infection.
"Inducible transfer of conjugative transposon Tn1545 from Enterococcus faecalis to Listeria monocytogenes in the digestive tracts of gnotobiotic mice." Antimicrob Agents Chemother., 35(1):185-7.
The liver metabolic profile of gnotobiotic mice is different from that of conventionally raised mice, probably because of an over influx of SCFAs into the liver.
However, because early microbe exposure significantly affects immune development and other physiological functions, the results of some gnotobiotic experiments may not reflect what occurs in animals that have been exposed to microbes since birth [188].
Duncan, "Influence of plant and bacterial myrosinase activity on the metabolic fate of glucosinolates in gnotobiotic rats," British Journal of Nutrition, vol.
Nicoli, "Effect of Saccharomyces boulardii against experimental oral infection with Salmonella typhimurium and Shigella flexneri in conventional and gnotobiotic mice," Journal of Applied Bacteriology, vol.
A spiral-bound technical handbook for research labs and lab workers, this book is a husbandry guide for keeping and doing experiments using germ-free and gnotobiotic mice.